Sodium phenylbutyrate

Aliases: 4-Phenylbutyric acid sodium salt, 4-PB, PBNa
Catalog No: 14032 Format: 5 g $90 Buy
Catalog No: 14033 Format: 1 g $30 Buy
Application: Histone Acetylation (HAT & HDAC)

Chemical Properties

MW = 186.2
C10H11O2 Na
CAS 1716-12-7
>98% (TLC; 5% CH3OH in CH2Cl2, Rf = 0.36); NMR (Conforms)

Description

Histone deacetylase (HDAC) inhibitor. Inhibits proliferation, migration and invasion of a number of cancer cell lines. Induces differentiation, and apoptosis. Active in vivo.

Contents

White powder. May be dissolved in DMSO (4 mg/ml); Water (25 mg/ml).

Storage Conditions

Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.

References

1. HH Engelhard et al. J. Neuro-Oncol. 1998, 37:97
2. IB Appelskog et al. Int. J. Oncol. 2004, 24:1419

 
Chemical structure of Sodium phenylbutyrate.

Chemical structure of Sodium phenylbutyrate.