Trichostatin A

Aliases: TSA, (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Catalog No: 14038 Format: 5 mg $320 Buy
Catalog No: 14039 Format: 1 mg $85 Buy
Application: Histone Acetylation (HAT & HDAC)

Chemical Properties

MW = 302.4
CAS 58880-19-6
MP = 150-151°C
>99% (HPLC); NMR (Conforms)


Potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM)(ref 1). Induces reversion of ras-transformed cells to normal morphology (ref 2). Induces dedifferentiation of primordial germ cells into embryonic germ cells (ref 3). Cell permeable. Active in vivo.


Tan powder. May be dissolved in DMSO (15 mg/ml); Ethanol (3 mg/ml).

Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.


1. M Yoshida et al. J. Biol. Chem. 1990, 265:17174
2. M Futamura et al. Oncogene 1995, 10:1119
3. G Durcova-Hills et al. PLoS-One 2008, 3:e3531

Chemical structure of Trichostatin A.

Chemical structure of Trichostatin A.