Aliases: (E)-N-hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide
Catalog No: 14044 Format: 25 mg $265 Buy
Catalog No: 14045 Format: 5 mg $75 Buy
Application: Histone Acetylation (HAT & HDAC)

Chemical Properties

MW = 349.4
CAS 404950-80-7
≥98% (TLC); NMR (Conforms)


A potent inhibitor of class I and II HDACs (ref 1). Cotreatment with panobinostat and an HSP90 inhibitor caused synergistic apoptosis in human CML-BC and AML cells (ref 2). A potent antimyeloma agent that overcomes drug resistance (ref 3).


Off white powder. May be dissolved in DMSO (100 mg/ml); Ethanol (5 mg/ml warm).

Storage Conditions

Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 1 month.


1. L Geng et al. Cancer Res. 2006, 66:11298
2. P George et al. Blood 2005, 105:1768
3. P Maiso et al. Cancer Res. 2006, 66:5781

Chemical structure of Panobinostat.

Chemical structure of Panobinostat.