Aliases: 3-Bromo-N-(3-(ter-butylamino)propyl)benzamide, hydrochloride
Catalog No: 14120 Format: 25 mg $225 Buy
Catalog No: 14121 Format: 5 mg $75 Buy
Application: Other

Chemical Properties

MW = 349.7
C14H21BrN2O • HCl
CAS 1648707-58-7
MP = 162-164°C
>98% (TLC); NMR (Conforms)


The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-stranded DNA breaks. UNC-2170, identified by screening, was found to be a µM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain (ref 1).


White powder. May be dissolved in DMSO (40 mg/ml); or water (50 mg/ml).

Storage Conditions

Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 3 months.


1. MT Perfetti et al. ACS Chem. Biol. 2015, 10:1072


Chemical structure of UNC-2170.