|Aliases: 3-Bromo-N-(3-(ter-butylamino)propyl)benzamide, hydrochloride|
|Catalog No: 14120||Format: 25 mg||$225||Buy|
|Catalog No: 14121||Format: 5 mg||$75||Buy|
MW = 349.7
C14H21BrN2O • HCl
MP = 162-164°C >98% (TLC); NMR (Conforms)
The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-stranded DNA breaks. UNC-2170, identified by screening, was found to be a µM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain (ref 1).
White powder. May be dissolved in DMSO (40 mg/ml); or water (50 mg/ml).
Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 3 months.
1. MT Perfetti et al. ACS Chem. Biol. 2015, 10:1072