Recombinant BRPF1 (1077-1205), GST-Tag

Aliases: BR140, Peregrin
Catalog No: 31484 Format: 100 µg $410 Buy
Catalog No: 31884 Format: 1 mg $2,600 Buy
Expressed In: E. coli Protein Species: Human

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Recombinant BRPF1 (1077-1205), GST-Tag protein expressed in E. coli and supplied in 25 mM Tris pH 7.4, 150 mM NaCl and 5% glycerol. Please refer to product insert upon arrival for lot-specific concentration.


Bromodomain and PHD finger containing (BRPF1) protein is a component of the MOZ/MORF complex which has histone H3 acetyltransferase activity. The bromodomain of BRPF1 recognizes acetylated histone lysine residues and function as a ‘reader’ of these epigenetic histone marks to regulate chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. BRPF1 is known to positively regulate the transcription of RUNX1 and RUNX2.
BRPF1 possesses a PWWP (Pro-Trp-Trp-Pro) domain that functions in the association of PWWP domain-containing proteins with chromatin. PWWP domains have been shown to bind DNA and also specifically recognized methylated lysine residues of histones. In doing so they are suspected to be involved in the mediation of the cross-talk between DNA and histone epigenetic marks. Mutations in PWWP domains have been shown to be associated with various human diseases, including cancer.

Application Notes

This product was manufactured as described in Protein Details. Where possible, Active Motif has developed functional or activity assays for recombinant proteins. Additional characterization such as enzyme kinetic activity assays, inhibitor screening or other biological activity assays may not have been performed for every product. All available data for a given product is shown on the lot-specific Technical Data Sheet.

Protein Details

The peptide corresponding to amino acids 1077 - 1205 that contains the PWWP domain sequences of BRPF1 (accession number NP_001003694.1) was expressed in E. coli and contains an N-terminal GST-Tag with an observed molecular weight of 42.8 kDa. The recombinant protein is >92% pure by SDS-PAGE.

BRPF1 (1077-1205), GST-Tag Coomassie gel

Recombinant BRPF1 (1077-1205), GST-Tag protein gel.
BRPF1 (1077-1205), GST-Tag protein was run on an SDS-PAGE gel and stained with Coomassie blue.


Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.


This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.