DR6 antibody (pAb)

Aliases: TNFRSF21, CD358, BM-018
Catalog No: 40927 Format: 100 µg $435 Buy

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Antibody Type:
Affinity Purified
Molecular Weight:
66 kDa


Western Blot Validated

Application Notes

Validated Applications:
WB: 1 - 2 µg/ml dilution

For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all Blotto solutions may also reduce background. Individual optimization may be required.


This DR6 antibody was raised against a cytoplasmic domain corresponding to amino acid residues 371-655 of human DR6.


PBS containing 0.02% sodium azide. Sodium azide is highly toxic.


DR6 antibody (pAb) tested by Western blot.

DR6 pAb tested by Western blot analysis.
Western blot analysis of 30 µg of total cell lysate from Jurkat (lane 1), HeLa (lane 2), and Daudi (lane 3) cells tested at 2 µg/ml.


DR6 (also known as Tumor Necrosis Factor Receptor Superfamily, member 21, TNFRSF21) is a member of the TNF-receptor superfamily. This receptor interacts with TRADD to mediate signal transduction of TNF receptors. It may activate NFκB (NFκB p50 and NFκB p65) and MAPK8/JNK and induce apoptosis.

Positive Control

Active Motif's HeLa whole-cell extract (Catalog No. 40050) can be used as a positive control for DR6 antibody.


Some products may be shipped at room temperature. This will not affect their stability or performance. Upon receipt, unconjugated antibodies may be stored at -20°C for up to 2 years. Fluorophore- & enzyme-conjugated antibodies should be stored at 4°C. Fluorophore-conjugated antibodies should be protected from light. Keep reagents on ice when not in storage; to avoid repeated freeze/thaw cycles, we recommend aliquoting items that will be stored frozen into single-use fractions prior to freezing.


This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.

Application Key

  • ChIP = Chromatin Immunoprecipitation;
  • DB = Dot Blot;
  • ELISA = Enzyme-linked Immunosorbent Assay;
  • EMSA = Electrophoretic Mobility Shift Assay
  • FC = Flow Cytometry;
  • ICC = Immunocytochemistry;
  • IF = Immunofluorescence;
  • IHC = Immunohistochemistry;
  • IP = Immunoprecipitation;
  • MeDIP = Methyl-DNA Immunoprecipitation;
  • TR-FRET = Time-Resolved Fluorescence Resonance Energy Transfer;
  • WB = Western Blotting