Caspase-8 antibody (mAb)

for Caspase-8 antibody (mAb) (Clone 90A992)Application Notes

Validated Applications:
WB: 1 - 2 µg/ml dilution

For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all Blotto solutions may also reduce background. Individual optimization may be required.

for Caspase-8 antibody (mAb) (Clone 90A992)Immunogen

This Caspase-8 antibody was raised against a synthetic peptide corresponding to amino acid residues 217-222 of human Caspase-8.

for Caspase-8 antibody (mAb) (Clone 90A992)Buffer

PBS containing 0.02% sodium azide. Sodium azide is highly toxic.

for Caspase-8 antibody (mAb) (Clone 90A992)References

for Caspase-8 antibody (mAb) (Clone 90A992)Background

Caspase-8 (CASP8 or apoptosis-related cysteine peptidase 8) is the most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adaptor molecule FADD recruits it to either receptor. Caspase-8 cleaves and activates Caspase-3, Caspase-4, Caspase-6, Caspase-7, Caspase-9 and Caspase-10.

for Caspase-8 antibody (mAb) (Clone 90A992)Storage

Some products may be shipped at room temperature. This will not affect their stability or performance. Upon receipt, unconjugated antibodies may be stored at -20°C for up to 2 years. Fluorophore- & enzyme-conjugated antibodies should be stored at 4°C. Fluorophore-conjugated antibodies should be protected from light. Keep reagents on ice when not in storage; to avoid repeated freeze/thaw cycles, we recommend aliquoting items that will be stored frozen into single-use fractions prior to freezing.

for Caspase-8 antibody (mAb) (Clone 90A992)Guarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.