AIRE antibody (pAb)
|Aliases: Autoimmune regulator, APECED, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy, APS1, APSI, PGA1|
|Catalog No: 61139||Format: 100 µl||$445||Buy|
|Catalog No: 61140||Format: 10 µl||$110||Buy|
WB: 1:500 - 1:1,000 dilution
This AIRE antibody was raised against a peptide in the C-terminal region of human AIRE.
Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
AIRE (Autoimmune regulator, APECED, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) is a DNA-binding transcriptional regulator that promotes the expression of tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions. AIRE functions as a dimer or as a tetramer and interacts with nucleosomes, selectively interacting with histone H3 unmodified in the N-terminus through its first of two PHD domains. Defects in AIRE are a cause of autoimmune poly-endocrinopathy candidiasis ectodermal dystrophy (APECED) also known as autoimmune polyglandular syndrome type I (APS-1).
Active Motif's Hep G2 nuclear extract (Catalog No. 36011) can be used as a positive control for AIRE antibody.
Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
This product is guaranteed for 12 months from date of receipt.
This product is for research use only and is not for use in diagnostic procedures.
- ChIP = Chromatin Immunoprecipitation;
- DB = Dot Blot;
- ELISA = Enzyme-linked Immunosorbent Assay;
- EMSA = Electrophoretic Mobility Shift Assay
- FC = Flow Cytometry;
- ICC = Immunocytochemistry;
- IF = Immunofluorescence;
- IHC = Immunohistochemistry;
- IP = Immunoprecipitation;
- MeDIP = Methyl-DNA Immunoprecipitation;
- WB = Western Blotting