Histone H3K23pr antibody (pAb)

Catalog No: 61397 Format: 100 µl $435 Buy
Catalog No: 61398 Format: 10 µl $105 Buy

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Antibody Type:
Polyclonal
Isotype:
IgG
Purification:
None
Host:
Rabbit
Molecular Weight:
17 kDa
Reactivity:
Human

Applications

Western Blot Validated Dot Blot Validated

Application Notes


Published Applications:
WB
DB
See references for more information. Individual optimization may be required.

Immunogen

This antibody was raised against a synthetic peptide corresponding to propionyl-Lys23 human Histone H3.

Buffer

Rabbit serum containing 30% glycerol and 0.035% sodium azide.

View our Guide to Histone Modifications and Biological Function.

References

Background

Propionylation of lysines is a recently identified post-translational modification and has been demonstrated to occur in proteins including histones and non-histone substrates, such as p53. Propionylation of Lys23 of Histone H3 may be catalyzed by the histone acetyltransferase p300 and may be removed by histone deacetylase Sir2. H3K23 proprionylation may play an important role in the epigenetic regulation of cell metabolism.

Storage

Some products may be shipped at room temperature. This will not affect their stability or performance. Upon receipt, unconjugated antibodies may be stored at -20°C for up to 2 years. Fluorophore- & enzyme-conjugated antibodies should be stored at 4°C. Fluorophore-conjugated antibodies should be protected from light. Keep reagents on ice when not in storage; to avoid repeated freeze/thaw cycles, we recommend aliquoting items that will be stored frozen into single-use fractions prior to freezing.

Guarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.

Application Key

  • ChIP = Chromatin Immunoprecipitation;
  • DB = Dot Blot;
  • ELISA = Enzyme-linked Immunosorbent Assay;
  • EMSA = Electrophoretic Mobility Shift Assay
  • FC = Flow Cytometry;
  • ICC = Immunocytochemistry;
  • IF = Immunofluorescence;
  • IHC = Immunohistochemistry;
  • IP = Immunoprecipitation;
  • MeDIP = Methyl-DNA Immunoprecipitation;
  • TR-FRET = Time-Resolved Fluorescence Resonance Energy Transfer;
  • WB = Western Blotting