DNA Methylation and Cancer eBook
An In-Depth Review of Studying DNA Methylation in Cancer Research
This DNA Methylation and Cancer eBook provides a comprehensive in-depth review of DNA methylation, DNA hydroxymethylation, as well as other DNA methylation variants. The tools available to study DNA methylation in cells or tissue are also discussed.
- Introduction to epigenetics and cancer
- Details of DNA methylation, hydroxymethylation, and other DNA methylation variants
- Tools to analyze DNA methylation
- Case study involving analysis of global DNA methylation levels and specific histone modifications in cancer
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Role of Epigenetics in Cancer
Genetic changes such as mutations to tumor suppressors and chromosomal translocations that activate oncogenes have long been known to play a role in the development and progression of various types of cancers. More recently, epigenetic changes such as different DNA methylation or histone modification patterns have also been shown to be important in cancer biology.
The link between epigenetics and cancer was revealed by the identification of mutations in, or altered expression of, epigenetic regulator proteins in many different types of cancer. Mutations have been identified in all three major classes of epigenetic proteins: the Writers (enzymes that add epigenetic modifications to DNA, RNA, or protein), the Erasers (enzymes that remove these modifications), and the Readers (proteins that recognize and bind epigenetic modifications). Drug development strategies that target epigenetic enzymes and proteins have resulted in FDA-approved anti-cancer drugs and there are many more on the horizon.