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EX-527

Aliases: 6-Chloro-2,3,4,8-tetrahydro-1H-carbazole-1-carboxamide (racemic)
Catalog No: 14028 Format: 25 mg $335 Buy Now
Catalog No: 14029 Format: 5 mg $90 Buy Now
Application: Sirtuins

for EX-527Chemical Properties

MW = 248.7
C13H13ClN2O
CAS 49843-98-3
>98% (TLC); NMR (Conforms)

for EX-527Description

Selective SIRT1 inhibitor (IC50 = 98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation following DNA damage (ref 1). Causes cell cycle arrest at G1 (ref 2). Inhibits differentiation and facilitates expansion of hematopoietic progenitor cells (ref 3). An extremely useful tool for determining the involvement of SIRT1 in cellular physiology (ref 4). Cell permeable.

for EX-527Contents

Light yellow powder. May be dissolved in DMSO (18 mg/ml); Ethanol (10 mg/ml).

for EX-527Storage Conditions

Store desiccated as supplied at 4°C for up to 2 years. Store solutions at -20°C for up to 2 months.

for EX-527References

1. JM Solomon et al. Mol. Cell Biol. 2006, 26:28
2. B Peck et al. Mol. Cancer Ther. 2010, 9:844
3. T Peled et al. Exp. Hematol.. 2012, 40:342
4. JL Andersen et al. Mol. Cell 2011, 43:834

 
Chemical structure of EX-527.

Chemical structure of EX-527.

 

Technical Data Sheet

EX-527
 

Data Thumbnails

Chemical structure of EX-527.

Chemical structure of EX-527.
(Click image to enlarge.)