Active Motif,
Tools to analyze nuclear function,
Your CartYour Cart 0 items

STAY INFORMED

Sign up to receive new product updates
and promotional pricing.

Active Motif

Dysregulation of miRNAs in Cancer

MicroRNAs (miRNAs) regulate a wide variety of biological processes, including development, differentiation, proliferation and apoptosis. Therefore, it is not surprising that expression levels of specific miRNAs have been shown to be changed, both up- and downregulated, in many different human cancers. Active Motif offers many different products and services for studying miRNA-3´UTR interactions and performing miRNA target validation (see right column).

Researchers studying the role of miRNAs in cancer may find the miRCancer website1 to be useful for uncovering relevant publications. It contains a comprehensive, searchable database of miRNA expression profiles in various human cancers that were automatically extracted from published literature through text mining of PubMed. To ensure 100% accuracy, the curators manually confirm all miRNA–cancer associations after automatic extraction.

The table below is only a small subset of the information available at the miRCancer website; it displays links to miRNA mimics and inhibitors that are sold by Active Motif for a small number of the cancers that are listed at miRCancer (as of their Dec. 7, 2014 update). For more complete, updated information on miRNAs that have been shown to be dysregulated in cancers, go to the miRCancer website.

Molecular model of hsa-miR-17, which is believed to play a role in many types of cancer.

Human miR-17, which is believed to play a role in many different types of cancer.

miRNAs Up or Downregulated in Cancers

  Links to LightSwitch™ miRNA Mimics & Inhibitors
Bladder Cancer mir-1, mir-10b, mir-16, mir-17, mir-18a, mir-19a, mir-23a, mir-23b, mir-26a, mir-26b, mir-29c, mir-96, mir-99a, mir-101, mir-124, mir-125b, mir-126, mir-137, mir-141, mir-143, mir-144, mir-145, mir-155, mir-182, mir-183, mir-185, mir-192, mir-195, mir-200a, mir-200b, mir-200c, mir-203, mir-205, mir-210, mir-221, mir-222, mir-223, mir-320c, mir-370, mir-409, mir-429, mir-490, mir-493, mir-639, mir-1236, mir-1280
Breast Cancer let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, mir-7, mir-10b, mir-15a, mir-16, mir-17, mir-18a, mir-18b, mir-19a, mir-19b, mir-20a, mir-20b, mir-21, mir-22, mir-23a, mir-24, mir-26a, mir-26b, mir-27a, mir-29a, mir-29b, mir-29c, mir-30a, mir-31, mir-34a, mir-34b, mir-34c, mir-92a, mir-96, mir-98, mir-99a, mir-100, mir-107, mir-122, mir-124, mir-125a, mir-125b, mir-126, mir-127, mir-129, mir-132, mir-135a, mir-140, mir-141, mir-142, mir-143, mir-145, mir-146a, mir-146b, mir-147a, mir-148a, mir-149, mir-150, mir-152, mir-155, mir-181a, mir-181b, mir-182, mir-183, mir-185, mir-191, mir-193a, mir-193b, mir-195, mir-199b, mir-200a, mir-200b, mir-200c, mir-203, mir-205, mir-206, mir-216b, mir-218, mir-221, mir-222, mir-224, mir-300, mir-335, mir-339, mir-373, mir-374a, mir-378a, mir-379, mir-381, mir-383, mir-425, mir-429, mir-450b, mir-495, mir-497, mir-502, mir-510, mir-517a, mir-520c, mir-574, mir-638, mir-720, mir-874, mir-1258
Cervical Cancer mir-10a, mir-17, mir-19a, mir-19b, mir-20a, mir-21, mir-29a, mir-31, mir-34a, mir-99a, mir-99b, mir-100, mir-101, mir-106a, mir-124, mir-143, mir-145, mir-148a, mir-155, mir-181a, mir-181b, mir-196a, mir-203, mir-205, mir-214, mir-215, mir-218, mir-224, mir-342, mir-372, mir-424, mir-497, mir-590, mir-944
Colon Cancer let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, mir-18a, mir-22, mir-23a, mir-25, mir-30a, mir-31, mir-34a, mir-34c, mir-93, mir-98, mir-101, mir-126, mir-142, mir-143, mir-145, mir-155, mir-181a, mir-182, mir-186, mir-192, mir-200c, mir-215, mir-221, mir-320a, mir-365, mir-373, mir-424, mir-455, mir-484, mir-502, mir-503, mir-627, mir-675, mir-1290
Colorectal Cancer let-7a, mir-1, mir-7, mir-15a, mir-15b, mir-16, mir-17, mir-18a, mir-19a, mir-19b, mir-20a, mir-21, mir-22, mir-23a, mir-25, mir-26b, mir-27a, mir-28, mir-29a, mir-29b, mir-30a, mir-30b, mir-31, mir-32, mir-34a, mir-92a, mir-93, mir-95, mir-96, mir-100, mir-101, mir-106a, mir-124, mir-125a, mir-125b, mir-126, mir-129, mir-130b, mir-132, mir-135a, mir-135b, mir-137, mir-138, mir-139, mir-143, mir-145, mir-148a, mir-148b, mir-150, mir-154, mir-155, mir-181a, mir-182, mir-183, mir-191, mir-192, mir-193a, mir-194, mir-195, mir-196a, mir-198, mir-199a, mir-200c, mir-202, mir-203, mir-204, mir-210, mir-211, mir-212, mir-215, mir-218, mir-221, mir-223, mir-224, mir-320a, mir-320b, mir-328, mir-338, mir-342, mir-345, mir-378a, mir-422a, mir-424, mir-429, mir-451a, mir-497, mir-498, mir-499a, mir-574, mir-625, mir-630, mir-638, mir-720, mir-1179, mir-1229, mir-1246
Esophageal Cancer let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, mir-9, mir-10b, mir-16, mir-17, mir-18a, mir-19a, mir-19b, mir-20a, mir-21, mir-22, mir-25, mir-27a, mir-29c, mir-30a, mir-31, mir-92a, mir-96, mir-98, mir-99a, mir-100, mir-101, mir-126, mir-138, mir-140, mir-143, mir-145, mir-146b, mir-150, mir-183, mir-185, mir-195, mir-196a, mir-197, mir-199a, mir-199b, mir-200a, mir-200b, mir-203, mir-210, mir-214, mir-223, mir-302b, mir-373, mir-451a, mir-518b, mir-655
Gastric Cancer let-7a, let-7b, let-7g, mir-7, mir-9, mir-10a, mir-10b, mir-17, mir-18a, mir-19a, mir-19b, mir-20a, mir-21, mir-22, mir-23a, mir-23b, mir-24, mir-25, mir-26a, mir-27a, mir-27b, mir-29a, mir-29b-1, mir-29b-2, mir-29b, mir-29c, mir-30a, mir-30b, mir-31, mir-34a, mir-34b, mir-34c, mir-92a, mir-98, mir-99a, mir-100, mir-101, mir-106a, mir-106b, mir-107, mir-122, mir-124, mir-125a, mir-125b, mir-126, mir-127, mir-129, mir-129-1, mir-129-2, mir-130b, mir-135a, mir-135b, mir-137, mir-138, mir-141, mir-143, mir-145, mir-146a, mir-147a, mir-148a, mir-148b, mir-149, mir-150, mir-152, mir-155, mir-181a, mir-181a-2, mir-181b, mir-181c, mir-182, mir-183, mir-185, mir-191, mir-192, mir-194, mir-195, mir-196a, mir-196b, mir-197, mir-199a, mir-200a, mir-200b, mir-200c, mir-202, mir-204, mir-205, mir-206, mir-210, mir-212, mir-214, mir-215, mir-218, mir-221, mir-222, mir-223, mir-224, mir-296, mir-301a, mir-302b, mir-302f, mir-328, mir-331, mir-335, mir-337, mir-338, mir-340, mir-370, mir-373, mir-378a, mir-409, mir-410, mir-421, mir-425, mir-429, mir-433, mir-449a, mir-494, mir-497, mir-503, mir-520c, mir-520d, mir-542, mir-544a, mir-575, mir-601, mir-616, mir-622, mir-625, mir-638, mir-650, mir-663a, mir-874, mir-1207, mir-1228, mir-1266, mir-1271, mir-1303
Glioblastoma let-7g, mir-7, mir-10b, mir-18a, mir-21, mir-29b, mir-31, mir-34a, mir-92b, mir-100, mir-101, mir-106a, mir-124, mir-125a, mir-125b, mir-127, mir-128, mir-129, mir-136, mir-137, mir-142, mir-143, mir-145, mir-146b, mir-148a, mir-149, mir-152, mir-153, mir-195, mir-196a, mir-196b, mir-210, mir-219, mir-222, mir-223, mir-320a, mir-326, mir-330, mir-331, mir-340, mir-342, mir-376a, mir-483, mir-503, mir-576, mir-626
Glioma let-7a, mir-7, mir-9, mir-10b, mir-15b, mir-16, mir-17, mir-19a, mir-19b, mir-20a, mir-23a, mir-23b, mir-24, mir-26a, mir-26b, mir-27a, mir-27b, mir-29c, mir-30a, mir-30e, mir-33a, mir-34a, mir-34c, mir-92b, mir-93, mir-96, mir-98, mir-106a, mir-106b, mir-107, mir-122, mir-124, mir-125b, mir-128, mir-132, mir-136, mir-137, mir-139, mir-143, mir-145, mir-146a, mir-146b, mir-152, mir-155, mir-181a, mir-181b, mir-181c, mir-181d, mir-182, mir-183, mir-184, mir-185, mir-193b, mir-195, mir-200a, mir-200b, mir-203, mir-204, mir-205, mir-210, mir-218, mir-219, mir-221, mir-222, mir-224, mir-326, mir-328, mir-335, mir-372, mir-383, mir-451a, mir-452, mir-483, mir-486, mir-494, mir-495, mir-497, mir-566, mir-622, mir-650, mir-656, mir-675
Head and Neck Cancer let-7d, mir-1, mir-16, mir-21, mir-25, mir-27a, mir-29a, mir-29b, mir-29c, mir-30a, mir-34a, mir-93, mir-106b, mir-107, mir-134, mir-138, mir-149, mir-200c, mir-205, mir-218, mir-300, mir-363, mir-874
Hepatocellular Carcinoma let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, mir-1, mir-7, mir-10b, mir-15b, mir-16, mir-17, mir-20a, mir-20b, mir-21, mir-22, mir-23a, mir-24, mir-25, mir-26a, mir-26b, mir-29a, mir-29b, mir-29c, mir-30a, mir-30d, mir-31, mir-33a, mir-34a, mir-34b, mir-92a, mir-96, mir-98, mir-99a, mir-100, mir-101, mir-105, mir-106b, mir-122, mir-124, mir-125b, mir-126, mir-127, mir-128, mir-130a, mir-130b, mir-134, mir-137, mir-138, mir-139, mir-140, mir-141, mir-142, mir-143, mir-144, mir-145, mir-146a, mir-148a, mir-148b, mir-155, mir-181a, mir-181b, mir-181c, mir-181d, mir-182, mir-183, mir-184, mir-185, mir-190b, mir-191, mir-195, mir-197, mir-198, mir-199a, mir-199b, mir-200a, mir-200b, mir-200c, mir-202, mir-203, mir-205, mir-206, mir-210, mir-212, mir-214, mir-215, mir-216a, mir-217, mir-218, mir-219, mir-221, mir-222, mir-223, mir-224, mir-301a, mir-302b, mir-302c, mir-335, mir-338, mir-362, mir-370, mir-371a, mir-372, mir-373, mir-376a, mir-422a, mir-423, mir-424, mir-429, mir-433, mir-451a, mir-452, mir-483, mir-485, mir-490, mir-494, mir-495, mir-497, mir-501, mir-503, mir-506, mir-519d, mir-520c, mir-520g, mir-574, mir-590, mir-612, mir-625, mir-637, mir-650, mir-657, mir-664, mir-675, mir-885, mir-941, mir-1228, mir-1271
Lung Cancer let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, mir-1, mir-7, mir-15a, mir-15b, mir-16, mir-17, mir-18a, mir-19a, mir-19b, mir-20a, mir-21, mir-22, mir-24, mir-26a, mir-26b, mir-29b, mir-29c, mir-30d, mir-31, mir-34a, mir-34b, mir-34c, mir-92a, mir-98, mir-99a, mir-99b, mir-101, mir-135b, mir-138, mir-141, mir-142, mir-145, mir-146a, mir-150, mir-153, mir-155, mir-182, mir-183, mir-192, mir-193a, mir-194, mir-195, mir-197, mir-198, mir-200a, mir-200b, mir-200c, mir-203, mir-205, mir-210, mir-217, mir-218, mir-223, mir-365, mir-381, mir-409, mir-429, mir-449a, mir-449b, mir-451a, mir-486, mir-511, mir-545, mir-610, mir-614, mir-630, mir-663a, mir-1297
Malignant Melanoma let-7b, mir-7, mir-9, mir-15b, mir-17, mir-18a, mir-18b, mir-20a, mir-21, mir-26a, mir-31, mir-34a, mir-34c, mir-92a, mir-98, mir-101, mir-125b, mir-126, mir-141, mir-143, mir-146a, mir-146b, mir-155, mir-182, mir-184, mir-185, mir-193b, mir-200a, mir-200b, mir-200c, mir-203, mir-204, mir-205, mir-206, mir-210, mir-211, mir-214, mir-218, mir-221, mir-222, mir-376a, mir-376c, mir-429, mir-532, mir-573, mir-1280
Non-Small Cell Lung Cancer let-7a, let-7c, mir-1, mir-9, mir-10b, mir-16, mir-17, mir-18a, mir-19a, mir-21, mir-22, mir-24, mir-25, mir-27a, mir-27b, mir-29a, mir-29b, mir-29c, mir-30a, mir-30b, mir-30c, mir-30d, mir-30e, mir-31, mir-34a, mir-34b, mir-92b, mir-93, mir-95, mir-96, mir-99a, mir-100, mir-101, mir-106a, mir-107, mir-124, mir-125a, mir-126, mir-136, mir-138, mir-140, mir-141, mir-142, mir-143, mir-145, mir-146a, mir-146b, mir-148a, mir-148b, mir-149, mir-152, mir-155, mir-181b, mir-186, mir-193b, mir-195, mir-196a, mir-199a, mir-200a, mir-200c, mir-204, mir-205, mir-212, mir-221, mir-222, mir-224, mir-328, mir-335, mir-338, mir-339, mir-340, mir-361, mir-373, mir-429, mir-449a, mir-451a, mir-497, mir-503, mir-625
Oral Cancer let-7d, mir-9, mir-10b, mir-21, mir-24, mir-27b, mir-29a, mir-31, mir-100, mir-124, mir-125b, mir-126, mir-136, mir-145, mir-146a, mir-146b, mir-147a, mir-148a, mir-155, mir-181a, mir-181b, mir-196a, mir-196b, mir-206, mir-218, mir-221, mir-222, mir-323, mir-329, mir-338, mir-345, mir-370, mir-410, mir-499a, mir-503, mir-632, mir-646, mir-668, mir-1250
Osteosarcoma mir-1, mir-9, mir-16, mir-17, mir-18a, mir-19a, mir-19b, mir-20a, mir-21, mir-22, mir-23a, mir-24, mir-26a, mir-27a, mir-29b, mir-32, mir-34a, mir-34c, mir-92a, mir-100, mir-124, mir-125b, mir-126, mir-127, mir-128, mir-132, mir-141, mir-142, mir-143, mir-144, mir-145, mir-151, mir-181a, mir-181b, mir-181c, mir-183, mir-191, mir-194, mir-195, mir-199a, mir-210, mir-214, mir-217, mir-218, mir-221, mir-320a, mir-335, mir-340, mir-376c, mir-381, mir-424, mir-429, mir-451a, mir-519d, mir-646, mir-802
Ovarian Cancer let-7i, mir-7, mir-9, mir-20a, mir-21, mir-23b, mir-25, mir-26a, mir-27a, mir-27b, mir-34a, mir-34b, mir-34c, mir-96, mir-98, mir-100, mir-101, mir-106a, mir-124, mir-125b, mir-130b, mir-137, mir-138, mir-141, mir-145, mir-148a, mir-148b, mir-152, mir-155, mir-181b, mir-182, mir-192, mir-193a, mir-199a, mir-200a, mir-200b, mir-200c, mir-212, mir-214, mir-221, mir-224, mir-335, mir-346, mir-372, mir-373, mir-378a, mir-409, mir-411, mir-424, mir-429, mir-432, mir-449a, mir-494, mir-497, mir-498, mir-503, mir-519d, mir-532, mir-655
Pancreatic Cancer let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g, let-7i, mir-7, mir-10a, mir-10b, mir-15a, mir-16, mir-17, mir-18a, mir-21, mir-27a, mir-30b, mir-31, mir-34a, mir-34b, mir-34c, mir-92a, mir-96, mir-98, mir-99a, mir-124, mir-126, mir-132, mir-135a, mir-141, mir-143, mir-144, mir-145, mir-146a, mir-148a, mir-148b, mir-150, mir-152, mir-181a, mir-191, mir-192, mir-194, mir-196a, mir-198, mir-200a, mir-200b, mir-200c, mir-203, mir-212, mir-214, mir-216a, mir-217, mir-218, mir-221, mir-301a, mir-301b, mir-335, mir-337, mir-369, mir-373, mir-376a, mir-424, mir-494, mir-497, mir-541, mir-615, mir-630, mir-1181, mir-1247
Prostate Cancer let-7a, let-7c, mir-18a, mir-20a, mir-21, mir-23b, mir-26a, mir-26b, mir-29b, mir-30a, mir-30b, mir-30c, mir-30d, mir-30e, mir-31, mir-34a, mir-34b, mir-34c, mir-96, mir-100, mir-101, mir-105, mir-107, mir-125b, mir-128, mir-130b, mir-135a, mir-143, mir-145, mir-146a, mir-153, mir-154, mir-181a, mir-181b, mir-181c, mir-181d, mir-182, mir-183, mir-199b, mir-200b, mir-203, mir-204, mir-205, mir-212, mir-218, mir-221, mir-224, mir-330, mir-331, mir-374b, mir-429, mir-449a, mir-497, mir-628, mir-765, mir-940, mir-1296
Renal Cell Cancer let-7a, let-7d, let-7e, mir-1, mir-7, mir-21, mir-30c, mir-30d, mir-34a, mir-100, mir-106a, mir-122, mir-129, mir-135a, mir-138, mir-141, mir-142, mir-143, mir-145, mir-146a, mir-146b, mir-155, mir-182, mir-199a, mir-200c, mir-203, mir-204, mir-205, mir-206, mir-210, mir-218, mir-335, mir-509, mir-630, mir-646, mir-1233, mir-1285, mir-1291
Thyroid Cancer mir-16, mir-21, mir-26a, mir-34a, mir-34b, mir-101, mir-130b, mir-138, mir-144, mir-146a, mir-146b, mir-151, mir-155, mir-181a, mir-181a-2, mir-181b, mir-181c, mir-181d, mir-182, mir-195, mir-199a, mir-199b, mir-219, mir-221, mir-222, mir-339, mir-613

 

Reference

  1. miRCancer: a microRNA-cancer association database constructed by text mining on literature – Boya Xie; Qin Ding; Hongjin Han; Di Wu (2013) Bioinformatics 29(5): 638-644.

Active Motif is not affiliated with the miRCancer website in any way, and is not responsible for the information presented on the miRCancer website.