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Transcription factors are DNA-binding proteins capable of activating or repressing gene regulation. Transcription factors can operate alone or form homodimers and heterodimers. Some transcription factors, such as NFκB and STAT, must undergo phosphorylation before they can bind DNA, while other transcription factors respond to ligand binding. Because these proteins are important regulators of development and cell cycle control, Active Motif offers highly purified proteins for use in your transcription and DNA binding assays, including nuclear receptors and NFκB family proteins.
