Active Motif,
Tools to analyze nuclear function,
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Epigenetics & Chromatin

Activators / Inhibitors

small molecules for epigenetic research

Active Motif has a collection of small-molecule epigenetic modulators (activators and inhibitors) that target changes to DNA methylation and chromatin remodeling proteins, such as histones. These include targets to DNA Methyltransferases (DNMTs), Histone Acetyltransferases (HATs), Histone Deacetylases (HDACs), Histone Methyltransferases (HMTs), Histone Demethylases (HDMs) and a distinct set of chromatin readers, bromodomains. As epigenetic dysregulation is implicated in many diseases, these modulators represent important tools for researchers in their assay development and drug discovery initiatives.

A list of the available activators and inhibitors for epigenetic research is shown below. Please click on the small molecule name to view complete product information.

 
Name Application Format Cat No. Price  
2'-Deoxy-5-fluorocytidine DNMT inhibitor 250 mg 14108 $370 Buy Now
50 mg 14109 $95 Buy Now
5-Aza-2’-deoxycytidine (Decitabine) DNMT inhibitor 50 mg 14100 $405 Buy Now
10 mg 14101 $125 Buy Now
5-Azacytidine DNMT inhibitor 250 mg 14102 $85 Buy Now
50 mg 14103 $35 Buy Now
6-Thioguanine DNMT inhibitor 1 g 14126 $125 Buy Now
100 mg 14127 $35 Buy Now
AK-7 SIRT2 inhibitor 25 mg 14054 $270 Buy Now
5 mg 14055 $75 Buy Now
Apicidin HDAC Inhibitor 5 mg 14040 $270 Buy Now
1 mg 14041 $80 Buy Now
AS-8351 KDM5B lysine demethylase inhibitor 25 mg 14112 $275 Buy Now
5 mg 14113 $65 Buy Now
BIX-01294 G9a/GLP HMT inhibitor 25 mg 14072 $475 Buy Now
5 mg 14073 $145 Buy Now
BML-210 HDAC Inhibitor 25 mg 14048 $395 Buy Now
5 mg 14049 $105 Buy Now
BML-278 SIRT1 activator 25 mg 14024 $290 Buy Now
5 mg 14025 $80 Buy Now
C646 p300/CBP HAT inhibitor 25 mg 14052 $420 Buy Now
5 mg 14053 $115 Buy Now
Chaetocin SU(VAR)3-9 methyltransferase inhibitor 200 µg 14051 $85 Buy Now
CI-994 HDAC Inhibitor 25 mg 14092 $285 Buy Now
5 mg 14093 $80 Buy Now
CPTH2 Gcn5P HAT inhibitor 25 mg 14094 $285 Buy Now
5 mg 14095 $80 Buy Now
CTPB p300 HAT activator 25 mg 14064 $420 Buy Now
5 mg 14065 $135 Buy Now
CUDC-101 HDAC and receptor tyrosine kinase inhibitor 25 mg 14060 $555 Buy Now
5 mg 14061 $150 Buy Now
Daminozide KDM2/KDM7 HDM inhibitor 250 mg 14058 $140 Buy Now
50 mg 14059 $45 Buy Now
DMOG PHD/JMJD2A inhibitor 50 mg 14062 $295 Buy Now
10 mg 14063 $75 Buy Now
Embelin PCAF HAT inhibitor 50 mg 14118 $245 Buy Now
10 mg 14119 $55 Buy Now
EX-527 SIRT1 inhibitor 25 mg 14028 $330 Buy Now
5 mg 14029 $85 Buy Now
Garcinol p300/pCAF HAT inhbitor 50 mg 14076 $345 Buy Now
10 mg 14077 $90 Buy Now
GSK-J1 (cell impermeable) JMJD3/UTX inhibitor 25 mg 14068 $330 Buy Now
5 mg 14069 $85 Buy Now
GSK-J4 (cell permeable) JMJD3/UTX inhibitor 25 mg 14070 $330 Buy Now
5 mg 14071 $85 Buy Now
HPA (Hexyl-4-pentynoic acid) HDAC Inhibitor 50 mg 14034 $180 Buy Now
10 mg 14035 $45 Buy Now
IOX1 JMJD family inhibitor 25 mg 14056 $345 Buy Now
5 mg 14057 $90 Buy Now
JQ1 (racemic) BET bromodomain inhibitor 25 mg 14066 $500 Buy Now
5 mg 14067 $140 Buy Now
Mithramycin A DNMT1 inhibitor 5 mg 14128 $195 Buy Now
1 mg 14129 $50 Buy Now
ML-324 JMJD2 HDM inhibitor 25 mg 14078 $370 Buy Now
5 mg 14079 $95 Buy Now
MS-275 HDAC Inhibitor 25 mg 14042 $275 Buy Now
5 mg 14043 $85 Buy Now
NSC-663284 SETD8 KMT inhibitor 25 mg 14122 $375 Buy Now
5 mg 14123 $95 Buy Now
Panobinostat Class I and II HDAC inhibitor 25 mg 14044 $275 Buy Now
5 mg 14045 $85 Buy Now
PBIT JARID1 inhibitor 25 mg 14110 $235 Buy Now
5 mg 14111 $65 Buy Now
Phenylbutyrate Na HDAC Inhibitor 1 g 14033 $70 Buy Now
Piceatannol SIRT1 activator 25 mg 14036 $235 Buy Now
5 mg 14037 $65 Buy Now
Resveratrol SIRT1 activator 500 mg 14022 $235 Buy Now
100 mg 14023 $65 Buy Now
RG108 Non-nucleoside DNMT inhibitor 25 mg 14104 $240 Buy Now
5 mg 14105 $60 Buy Now
Romidepsin HDAC inhibitor 1 mg 14083 $245 Buy Now
RVX-208 BET bromodomain antagonist 25 mg 14090 $300 Buy Now
5 mg 14091 $85 Buy Now
Salermide Sirt1 & Sirt2 inhibitor 25 mg 14124 $275 Buy Now
5 mg 14125 $105 Buy Now
Sinefungin Methyltransferase inhibitor 5 mg 14088 $250 Buy Now
1 mg 14089 $70 Buy Now
SirtAct SIRT1 activator 25 mg 14080 $660 Buy Now
5 mg 14081 $155 Buy Now
Sirtinol Sirtuin inhibitor 25 mg 14074 $475 Buy Now
5 mg 14075 $115 Buy Now
Splitomicin Sir2p (yeast Sirt1 homolog) inhibitor 25 mg 14086 $245 Buy Now
5 mg 14087 $65 Buy Now
TC-E-5003 PRMT1 inhibitor 50 mg 14099 $65 Buy Now
TM-2-51 HDAC8 activator 50 mg 14096 $200 Buy Now
10 mg 14097 $55 Buy Now
Tranylcypromine hemisulfate LSD1/BHC110 inhibitor 250 mg 14046 $155 Buy Now
50 mg 14047 $50 Buy Now
Triacetyl resveratrol Sirt activator 250 mg 14116 $350 Buy Now
50 mg 14117 $140 Buy Now
Trichostatin A HDAC Inhibitor 5 mg 14038 $455 Buy Now
1 mg 14039 $145 Buy Now
Tubastatin A hydrochloride HDAC6 inhibitor 25 mg 14084 $395 Buy Now
5 mg 14085 $110 Buy Now
UNC1999 EZH1 & EZH2 lysine methyltransferase inhibitor 25 mg 14114 $325 Buy Now
5 mg 14115 $110 Buy Now
UNC-2170 Methyl-lysine Binding Protein Inhibitor 25 mg 14120 $450 Buy Now
5 mg 14121 $110 Buy Now
Valproic Acid, sodium salt HDAC Inhibitor 5 g 14021 $35 Buy Now
Vorinostat (SAHA) HDAC Inhibitor 50 mg 14026 $345 Buy Now
10 mg 14027 $90 Buy Now
Zebularine DNMT inhibitor 25 mg 14106 $250 Buy Now
5 mg 14107 $70 Buy Now