Active Motif,
Tools to analyze nuclear function,
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DNA Methylation

epigenetic modulators of DNA methylation

DNA Methylation is a common epigenetic signaling tool that is is used to control gene expression in eukaryotes. DNA methyltransferase enzymes (DNMTs) catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines. In mammalian cells, DNA methylation is generally associated with gene silencing and effects numerous cellular processes, including embryonic development, genomic imprinting, X-chromosome inactivation and preservation of chromosome stability. Hypermethylation of the promoters of tumor suppressor genes often occur in certain types of cancers.

Active Motif offers several small molecules that can be used to modify DNA methylation levels. Some molecules act as chemical analogs for the nucleoside cytidine that, when incorporated into growing DNA strands, will inhibit the DNMT enzymes that normally methylated DNA. Other compounds act as non-nucleoside DNA methylation inhibitors.

 
Name Application Format Cat No. Price  
2'-Deoxy-5-fluorocytidine DNMT inhibitor 250 mg 14108 $370 Buy Now
50 mg 14109 $95 Buy Now
5-Aza-2’-deoxycytidine (Decitabine) DNMT inhibitor 50 mg 14100 $405 Buy Now
10 mg 14101 $125 Buy Now
5-Azacytidine DNMT inhibitor 250 mg 14102 $85 Buy Now
50 mg 14103 $35 Buy Now
6-Thioguanine DNMT inhibitor 1 g 14126 $125 Buy Now
100 mg 14127 $35 Buy Now
Mithramycin A DNMT1 inhibitor 5 mg 14128 $195 Buy Now
1 mg 14129 $50 Buy Now
RG108 Non-nucleoside DNMT inhibitor 25 mg 14104 $240 Buy Now
5 mg 14105 $60 Buy Now
Sinefungin Methyltransferase inhibitor 5 mg 14088 $250 Buy Now
1 mg 14089 $70 Buy Now
Zebularine DNMT inhibitor 25 mg 14106 $250 Buy Now
5 mg 14107 $70 Buy Now