Your Cart
Browse
Filter
Active Motif offers recombinant proteins to study histones and their post-translational modifications. Our growing list of available recombinant histones include site- and degree-specific methylation, acetylation and phosphorylation. We also have a biotinylated histone H3 protein for use in FRET assays.
Each recombinant protein is made using our patented technologies. To generate the methylated histones we use a chemical alkylation reaction to introduce a methyl-lysine analog at the desired lysine location, giving us precise control over the site and degree of methylation. The acetylated histones and phosphorylated histones are created using a separate technology in which the histone globular domain is ligated to a peptide containing the N-terminal histone tail with site-specific modifications. This ligation reaction maintains the native histone bonds. All proteins are determined to be over 98% pure.
A complete list of recombinant histones are shown below. Click on the protein name to see complete information.
