Screen for active T-bet (T-box transcription factor expressed in T cells) with TransAM™ T-bet. T-bet is a transcription factor essential to T helper 1 (Th1) cell generation and effector function. Recently, the expression of T-bet has also been described in B, natural killer (NK), CD8+ T and dendritic cells. T-bet regulates expression of numerous immune system-associated genes, including cytokines, cytokine receptors, chemokines, chemokine receptors and cytotoxicity.


