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Sinefungin

Aliases: Sinefungin, 5'-Deoxy-5'-(1,4-diamino-4-carboxybutyl)adenosine; A-9145; Adenosylornithine; Antibiotic 32232RP
Catalog No: 14088 Format: 5 mg $255 Buy Now
Catalog No: 14089 Format: 1 mg $75 Buy Now
Application: DNA Methylation

for SinefunginChemical Properties

MW = 381.4
C15H23N7O5
CAS 58944-73-3
>98% (HPLC); NMR (Conforms)

for SinefunginDescription

Nucleoside S-adenosyl-1-methionine analog. Potent, competitive methyltransferase (protein, DNA, and RNA methyltransferase) inhibitor (Ref 1,2). IC50 > 1.0 and 2.5 µM for PRMT1 and SET7/9, respectively (ref 3). Binds with greater affinity to the adenine-specific DNA methyltransferase M.TaqI than S-adenosyl-L-homocysteine (ref 4). Inhibits biofilm formation by Streptococcus pneumoniae (ref 5).

for SinefunginContents

Tan powder. May be dissolved in water (20 mg/ml).

for SinefunginStorage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.

for SinefunginReferences

1. C Barbes et al. FEMS Microbiol. Lett. 1990, 57:239
2. MJ Yebra et al. J Antibiot. (Tokyo) 1991, 44:1141
3. D Cheng et al. J. Biol. Chem. 2004, 279:23892
4. G Schluckebier et al. J. Mol. Biol. 1997, 265:56
5. MK Yadav et al. Biomed. Res. Int. 2014, 2014:156987

 
Chemical structure of Sinefungin.

Chemical structure of Sinefungin.

 

Technical Data Sheet

Sinefungin
 

Data Thumbnails

Chemical structure of Sinefungin.

Chemical structure of Sinefungin.
(Click image to enlarge.)