STAT1α antibody (pAb)

for STAT1a antibody (pAb)Background

STAT1 is alternatively spliced to give rise to STAT1α and STAT1β, both of which mediate interferon α activity, but only STAT1α mediates interferon-γ activity. STAT1 plays a critical role in various forms of cell death, both apoptotic and non-apoptotic. The mechanisms of action are both by transcriptional activation of target genes, and by direct association with apoptotic regulators, including TRADD, p53, and HDAC (HDAC1, HDAC2, HDAC4, HDAC5, HDAC6 and HDAC11). STAT1 target genes include the pro-inflammatory genes for iNOS, COX, VCAM, and ICAM, making STAT1 an attractive anti-inflammatory target.

for STAT1a antibody (pAb)Immunogen

This STAT1α antibody was raised against a synthetic peptide corresponding to amino acid residues 712-750 of human STAT1α.

for STAT1a antibody (pAb)Application Notes

This STAT1α antibody has been validated for use in Western blotting (1:500 - 1:1,000 dilution). For optimal results, primary antibody incubations should be performed at 37°C. Individual optimization may be required.

for STAT1a antibody (pAb)Buffer

PBS containing 0.2% gelatin, 0.01% thimersol and 0.1% sodium azide.

for STAT1a antibody (pAb)Positive Control

Active Motif's T-47D nuclear extract (Catalog No. 36027) can be used as a positive control for STAT1α antibody.

for STAT1a antibody (pAb)Storage

Antibodies in solution can be stored at -80°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for STAT1a antibody (pAb)Guarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.