HNF-3β / FOXA2 antibody (pAb)

for HNF-3β / FOXA2 antibody pAbBackground

HNF-3β (Hepatocyte nuclear factor 3 beta, forkhead box A2, FoxA2) is a homeodomain containing transcription factor and is a member of the Hepatocyte Nuclear Factor family (HNF-1α, HNF-1β, HNF-3α, HNF-3β, HNF-3γ, HNF-4α, HNF-4γ, HNF-6α and HNF-6β), whose members regulate the transcription of numerous hepatocyte genes in adult liver. HNF-3 members bind to DNA as monomers using a winged helix DNA-binding domain. HNF-3α and HNF-3γ have also been shown to be involved in gastrulation events such as body axis formation.

for HNF-3β / FOXA2 antibody pAbImmunogen

This HNF-3β / FOXA2 antibody was raised against a recombinant protein corresponding to amino acids 7-86 of rat HNF-3β /FOXA2.

for HNF-3β / FOXA2 antibody pAbApplication Notes

This HNF-3β / FOXA2 antibody has been validated for use in Western blotting (1:2,000 - 1:5,000 dilution) and immunohistochemistry (see references).

for HNF-3β / FOXA2 antibody pAbBuffer

Rabbit serum containing 30% glycerol and 0.035% sodium azide.

for HNF-3β / FOXA2 antibody pAbPositive Control

Active Motif's HeLa nuclear extract (Catalog No. 36010) can be used as a positive control for HNF-3β / FOXA2 antibody.

for HNF-3β / FOXA2 antibody pAbReferences

This antibody has been used in immunohistochemsitry in the following reference: Wan H et al (2004) Development 131: 953-964

for HNF-3β / FOXA2 antibody pAbStorage

Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for HNF-3β / FOXA2 antibody pAbGuarantee

This product is for research use only and is not for use in diagnostic procedures. This product is guaranteed for 6 months from date of arrival.