Active Motif,
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Active Motif

What our Services customers say

Univ Pitt

Vijay K. Yechoor
Director
Diabetes and Beta Cell Biology Center
University of Pittsburgh
Pittsburgh, PA

“While working on mouse islet Chip-Seq and assessment of open chromatin, we decided to obtain the services from Active Motif EpiServices because of their experience with working with small samples. In this ongoing project, we are very happy with the data we are getting and intend to expand this to other tissues and also human islets.”
Univ Pitt Ning Feng, MD, PhD
Assistant Professor
Division of Cardiology
University of Pittsburgh

Pittsburgh, PA
“I have had a very good experience with Active Motif Epigenetic services and I will continue the research with Active Motif in the future. I am studying the epigenetic regulation of heart failure and I am interested in ATAC -Seq in heart failure. I decided to outsource the ATAC-Seq to Active Motif because I have limited knowledge and experience with this method. I received good support from both the Sales Department and the Tech Support Team to help me to go through all the aspects of the service.”

NIEHS Logo David W. Scoville, PhD
Postdoctoral Fellow
Immunity, Inflammation, and Disease Laboratory
National Institute of Environmental Health Sciences
Durham, NC
“We used Active Motif’s EpiServices for our ChIP-Seq project, due to the difficulties of working with very small amounts of tissue (mouse pancreatic islets). We found the results were impressive and of high quality. We will definitely consider using Active Motif for any future ChIP-Seq projects involving difficult tissue samples.”
NIEHS Logo Fei Zhao, PhD
Postdoctoral Fellow
Reproductive Developmental Biology Group
National Institute of Environmental Health Sciences
Durham, NC
“We used Active Motif EpiServices for our ChIP-Seq project. We liked the overall quality and the work. The Active Motif Epigenetic Service group is very helpful and responsive to our questions. Thanks!!”

DKFZ Logo David Jones, PhD
Senior Researcher
Pediatric Glioma Research
German Cancer Research Center (DKFZ)
Heidelberg, Germany
“I have been using Active Motif’s ChIP-Seq services for several years for histone tail modifications, epigenetic regulators and transcription factors. I have been consistently impressed with the professional customer service, as well as the speed of turnaround and the quality of data obtained from frozen human tumor specimens. I would not hesitate to recommend that people try the service for themselves.”

GSK Logo Palwinder Mander, PhD
Scientist
GlaxosmithKline
Collegeville, PA
“We used Active Motif’s EpiServices for our ChIP-Seq project. We were impressed by the overall quality and the collaborative approach they took on working with primary human immune cells - the work was a key contribution to our publication.”

Marburg Logo Dr. Till Adhikary, PhD
Scientist
Center for Tumor & Immunobiology
Phillips University
Marburg, Germany
"We used Active Motif's RIME services several times and found their protocol to be reliable and reproducible. Expected interactors were detected robustly and specifically.”
Marburg Logo Matthias Lauth, PhD
Scientist
Center for Tumor and Immunobiology
Phillips University
Marburg, Germany
“While working on the molecular mechanism of an epigenetic drug, we outsourced the Mod Spec. part to Active Motif in order to get a broader overview of the drug-induced changes of histone modifications. Overall, we were very pleased with the quality of the service, the kept timeline and last but not least, the fair price. We found surprising things that were not on our radar before.”

FSU Jena Logo Argyris Papantonis, PhD
Junior Group Leader in Systems Biology
Center for Molecular Medicine
University of Cologne
Cologne, Germany
“We used the AM ChIP-Seq service for a precious, low cell count, sample. We had genome-edited human endothelial cells to introduce a 300-bp insertion in chr14, and wanted to identify binding sites for the NF-KappaB transcription factor in the presence of this insertion. The AM team managed to produce >2,000 such sites using our limiting material, and the data aligned nicely with known peaks from non-edited endothelial cells. From the same cells the AM team also managed to perform ChIP-Seq for p300, which allowed us to discriminate between active and inactive NF-kappaB-bound enhancers. In the end, this data contributed to our work on the non-canonical binding modes of NF- kappaB during the immediate-early inflammatory response, and led to a publication in Genome Research (Kolovos et al, Genome Res, 2016).”

FSU Jena Logo Holger Bierhoff, PhD
Principal Investigator
Epigenetics of Aging
Friedrich Schiller University
Jena, Germany
“Conducting our ChIP-Mass-Spec (RIME) analysis with Active Motif was a breeze! We just sent our crosslinked cells and antibody and quickly got a nice list of interesting candidates back.”

USP Brazil Logo Fabiano Pinheiro da Silva, MD, PhD
Physician-scientist
Faculdade de Medicina da USP
University of São Paulo, Brazil
“The ChIP-Seq service a few years ago was excellent, it allowed me to proof that cathelicidin migrates to the nucleus and binds to promoter regions.”

City of Hope Logo Sangeeta Dhawan, PhD
Assistant Professor
Dept. Translational Research &
Cellular Therapeutics
City of Hope
Duarte, CA
“We used the Active Motif ChIP-Seq services for mapping binding sites for a specific transcription factor during mouse pancreatic beta cell development. The process of having our samples shipped to receiving analyzed data was very simple and the Active Motif team made each step very streamlined. They are very flexible in the type of samples they work with, single cell suspension, cell clusters etc. and provided very useful tips on sample preparation and shipment. They were also very helpful with providing further support even after completion of the project.”

Rutgers Logo Danish Sayed, PhD
Assistant Professor
Department of Cell Biology and Molecular Medicine
Rutgers University
Newark, NJ
“My research is focused on establishment and deconstruction of the active transcriptional machinery involved in gene regulation during heart failure. We have been using Active Motif for our ChIP-Sequencing and RNA-Sequencing services for more than five years, and have been extremely impressed by the quality, comprehensiveness and the understanding of our project needs with respect to actual data and bioinformatics analysis. We have successfully published our results in Journal of Biological Chemistry and Circulation: Heart Failure, and have two manuscripts in preparation based on the data generated through Active Motif.”

Univ Pitt Brian Corley, PhD
Acting Branch Chief
Integrated Systems Toxicology Division - Carcinogenesis Branch
Environmental Protection Agency
Durham, NC
“We worked with Active Motif to process some FFPE and frozen liver samples sourced from 25+year old samples for an RRBS assay. The overall process of submitting samples, communicating with Active Motif, receiving the data, and obtaining the summary was quick and painless. The whole operation was smooth and professionally done.  The data itself gave us confidence in using FFPE-sourced samples to assess DNA methylation using the RRBS method. While both frozen and FFPE samples were rather old, we received usable data, giving us confidence that FFPE is a viable option when determining genome-wide methylation levels in our archived samples.”

Mirati Logo David Briere, PhD
Principal Scientist
Mirati Therapeutics
San Diego, CA
"We have been investigating our HDAC inhibitor for a few years. We have observed robust single agent activity and regression in combination with a PD-L1 mouse antibody in our efficacy studies. We confirmed our compounds ability to increase antigen presentation machinery and modulate relevant immune cell populations. However, we wanted to investigate its mechanism of action. Enter Active Motif and their ChIP-Seq service. They took the time to listen to our questions, understand our goal and discuss all options and implications (financial and scientific). Not only did the ChIP-Seq study confirm our data-set, it also highlighted a novel mechanism. The quality of the data and service was amazing. The data has been presented at AACR and published in Cancer Immunology, Immunotherapy. Excellent science, informed and helpful people and quality data. Thank you.”

Baylor Daniel Lacorazza, PhD
Associate Professor
Baylor College of Medicine
Texas Children's Hospital
Houston, TX
"We used next-generation bisulfite sequencing and ChIP-seq services to describe tumor suppressor function of KLF4 in pediatric leukemias (Shen et al. Leukemia, 2017). The quality of this service including the bioinformatic analysis was outstanding and essential for our project.”

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