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Recombinant Proteins & Enzymes

Recombinant PRMT2 protein

Aliases: HRMT1L1
Catalog No: 31392 Format: 20 µg $425 Buy Now
Expressed In: Baculovirus Protein Species: Human

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for Recombinant PRMT2 proteinContents

Recombinant PRMT2 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 5% glycerol, 0.04% Triton X-100, 0.2 mM TCEP. Please refer to product insert upon arrival for lot-specific concentration.

for Recombinant PRMT2 proteinBackground

PRMT2 (Protein Arginine Methyltransferase 2) is a member of the protein arginine N-methyltransferase (PRMT) family that is capable of monomethylating and asymmetrically dimethylating arginine residues. PRMT2 methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, and histone H4. PRMT2, along with NCOA2, acts as a coactivator of androgen receptor (AR)-mediated transactivation. PRMT2 also acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. PRMT2 enhances PGR, PPARϒ, RARA-mediated transactivation and may inhibit NFκB transcription and promote apoptosis. PRMT2 is known to repress E2F1 transcriptional activity in an Rb-dependent manner and may be involved in growth regulation.

for Recombinant PRMT2 proteinApplication Notes

Recombinant PRMT2 is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.

Specific Activity: PRMT2 methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, and histone H4. May methylate H3R8 and H4.

for Recombinant PRMT2 proteinProtein Details

Recombinant PRMT2 was expressed in a baculovirus expression system as the full length protein (accession number NP_996845.1) with an N-terminal FLAG-Tag. The molecular weight of PRMT2 is 47.6 kDa. The purity of the protein is >75% by SDS-PAGE.

 
Recombinant PRMT2 protein gel.

Recombinant PRMT2 protein gel.
PRMT2 protein was run on an 8% SDS-PAGE gel and stained with Coomassie Blue.

for Recombinant PRMT2 proteinStorage

Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

for Recombinant PRMT2 proteinGuarantee

This product is guaranteed for 6 months from date of receipt.

This product is for research use only and is not for use in diagnostic procedures.

 

Technical Data Sheet

Recombinant PRMT2 protein
 

Data Thumbnails

Recombinant PRMT2 protein gel.

Recombinant PRMT2 protein, stained with Coomassie Blue.
(Click image to enlarge and see details).