Vorinostat (SAHA)

Aliases: Suberoylanilide-hydroxamic acid, SAHA
Catalog No: 14026 Format: 50 mg $125 Buy
Catalog No: 14027 Format: 10 mg $50 Buy
Application: Histone Acetylation (HAT & HDAC)

Chemical Properties

MW = 264.3
C14H20N2O3
CAS 149647-78-9
>98% (TLC); NMR (Conforms)

Description

Potent and selective histone deacetylase inhibitor (ref 1). Induces apoptosis in a variety of tumor cell lines (ref 2). Synergizes with kinase inhibitors to kill CNS tumor cells (ref 3). Prevents diabetes in a mouse model by immunoregulation and β-cell pretection (ref4). Cell permeable.

Contents

White powder. May be dissolved in DMSO (50 mg/ml); Ethanol (2 mg/ml).

Storage Conditions

Store desiccated as supplied at room temperature for up to 5 years. Store solutions at -20°C for up to 1 month.

References

1. JA Vrana et al. Oncogene 1999, 18:7016
2. LM Butler et al. Proc. Natl. Acad. Sci. USA 2002, 99:11700
3. Y Tang et al. Cancer Biol. Ther. 2012, 13:567
4. DP Christensen et al. Proc. Natl. Acad. Sci. USA 2014, 111:1055

 
Chemical structure of Vorinostat (SAHA).

Chemical structure of Vorinostat (SAHA).