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Functional Genomics - LightSwitch™
Gene Regulation
Epigenetics & Chromatin
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Antibody Labeling
Recombinant Proteins & Enzymes
- Recombinant Proteins
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- Histone Acetyltransferases (HATs) and Histone Deacetylases (HDACs)
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- Transcription Factors
- Ubiquitination
Protein Detection and Quantitation
- FACE™ In-cell Western Phospho ELISAs
- GTPase Activation Assay
- Kinase Assay Substrate
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Cell, Acid & Tissue Extracts
Fluorescence
- Fluorescent Dyes and Antibodies
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Sample Preparation
- Sonication Products
- Chromatin IP DNA Purification
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- Cell-Free DNA (cfDNA) Purification Kit
- Protein & Extract Quantification
- RNA Isolation
- Fluorescent Dye Labeling
- Mitochondrial Separation
- Dounce Homogenizer
Transfection & Expression
Epigenetics & Chromatin
Sirtuins (SIRT & Sir2)
Sirtuins are NAD-dependent deacetylases that are highly conserved among species. The original family member, Sir2 (silent mating-type information regulator 2) from yeast was identified as a gene involved in maintaining silent chromatin. In mammals, there are seven sirtuins (SIRT1-7) belonging to the class III histone deacetylase (HDAC) family of proteins. These are the only HDACs that require NAD for their enzymatic activity. Sirtuins play a role in metabolic diseases, neuronal physiology and aging, making them an important area of research.
Active Motif offers several activators and inhibitors to study the effects of Sirtuins.
| Name | Appl. | Format | Cat No. | Price | |
|---|---|---|---|---|---|
| AK-7 | SIRT2 Inhibitor | 25 mg | 14054 | $260 | Buy |
| 5 mg | 14055 | $65 | Buy | ||
| BML-278 | SIRT1 Activator | 25 mg | 14024 | $285 | Buy |
| 5 mg | 14025 | $75 | Buy | ||
| EX-527 | SIRT1 Inhibitor | 25 mg | 14028 | $160 | Buy |
| 5 mg | 14029 | $45 | Buy | ||
| Piceatannol | SIRT1 Activator | 25 mg | 14036 | $225 | Buy |
| 5 mg | 14037 | $60 | Buy | ||
| Resveratrol | SIRT1 Activator | 500 mg | 14022 | $225 | Buy |
| 100 mg | 14023 | $55 | Buy | ||
| Salermide | SIRT Inhibitor | 25 mg | 14124 | $160 | Buy |
| 5 mg | 14125 | $40 | Buy | ||
| SirtAct | SIRT1 Activator | 25 mg | 14080 | $380 | Buy |
| 5 mg | 14081 | $150 | Buy | ||
| Sirtinol | SIRT Inhibitor | 25 mg | 14074 | $350 | Buy |
| 5 mg | 14075 | $100 | Buy | ||
| Splitomicin | Sir2p (yeast Sirt1 homolog) Inhibitor | 25 mg | 14086 | $220 | Buy |
| 5 mg | 14087 | $50 | Buy | ||
| Triacetyl resveratrol | SIRT Activator | 250 mg | 14116 | $210 | Buy |
| 50 mg | 14117 | $65 | Buy |
