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Stay up-to-date with the latest publications from our Epigenetics experts.

DNA Methylation & Cancer

The link between epigenetics and cancer has been substantiated through the identification of mutations in, or altered expression of, epigenetic regulator proteins in many different types of cancer. Mutations have been identified in all three major classes of epigenetic proteins: the Writers (enzymes that deposit modifications), the Erasers (enzymes that remove modifications) and the Readers (proteins that recognize and bind epigenetic modifications). Recent drug development strategies that target these enzymes have resulted in FDA approved cancer drugs with many more on the horizon.

microRNAs in Cancer

The recognition that carcinogenesis involves not only genetic but also epigenetic alterations has led to a better understanding of the molecular pathways that govern the development of cancer. The functional relevance of ncRNAs is particularly evident for microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), which have been associated with all stages of cancer including diagnosis, staging, progression, prognosis, and response to treatment. Their misexpression confers upon a cancer cell the capacity for tumor initiation, growth, and metastasis, making ncRNAs attractive therapeutic targets and potentially useful diagnostic tools.