Histone Methylation (HMT & HDM)

epigenetic modulators of HMTs & HDMs

Histone methylation is a reversible reaction that occurs on lysine or arginine residues of histone tails. Histone methyltransferases (HMTs) catalyze the transfer of a methyl group, while histone demethylases (HDMs) perform the antagonistic action of removing the methyl group. Lysine residues can be mono-, di- or tri-methylated and arginine residues can undergo asymmetric or symmetric dimethylation. Histone methylation plays an important role in transcriptional regulation.

Active Motif offers several small molecules to study the effect of changes in HMT and HDM activity.

 
Name Appl. Format Cat No. Price  
AS-8351 KDM5B Inhibitor 25 mg 14112 $200 Buy
5 mg 14113 $50 Buy
BIX-01294 G9a/GLP Inhibitor 25 mg 14072 $450 Buy
5 mg 14073 $100 Buy
Chaetocin SU(VAR)3-9 Methyltransferase Inhibitor 200 µg 14051 $80 Buy
Daminozide KDM2/KDM7 Inhibitor 250 mg 14058 $140 Buy
50 mg 14059 $45 Buy
DMOG PHD/JMJD2A Inhibitor 50 mg 14062 $180 Buy
10 mg 14063 $50 Buy
GSK-J1 (cell impermeable) JMJD3/UTX Inhibitor 25 mg 14068 $320 Buy
5 mg 14069 $80 Buy
GSK-J4 (cell permeable) JMJD3/UTX Inhibitor 25 mg 14070 $320 Buy
5 mg 14071 $80 Buy
IOX1 JMJD Family Inhibitor 25 mg 14056 $290 Buy
5 mg 14057 $75 Buy
JIB-04 JMJD Family Inhibitor 25 mg 14134 $225 Buy
5 mg 14135 $65 Buy
ML-324 JMJD2 Inhibitor 25 mg 14078 $340 Buy
5 mg 14079 $85 Buy