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Histone methylation is a reversible reaction that occurs on lysine or arginine residues of histone tails. Histone methyltransferases (HMTs) catalyze the transfer of a methyl group, while histone demethylases (HDMs) perform the antagonistic action of removing the methyl group. Lysine residues can be mono-, di- or tri-methylated and arginine residues can undergo asymmetric or symmetric dimethylation. Histone methylation plays an important role in transcriptional regulation.
Active Motif offers several small molecules to study the effect of changes in HMT and HDM activity.
| Name | Appl. | Format | Cat No. | Price | |
|---|---|---|---|---|---|
| AS-8351 | KDM5B Inhibitor | 25 mg | 14112 | $225 | Add to Cart |
| 5 mg | 14113 | $70 | Add to Cart | ||
| BIX-01294 | G9a/GLP Inhibitor | 25 mg | 14072 | $525 | Add to Cart |
| 5 mg | 14073 | $125 | Add to Cart | ||
| Chaetocin | SU(VAR)3-9 Methyltransferase Inhibitor | 200 µg | 14051 | $100 | Add to Cart |
| Daminozide | KDM2/KDM7 Inhibitor | 250 mg | 14058 | $180 | Add to Cart |
| 50 mg | 14059 | $60 | Add to Cart | ||
| DMOG | PHD/JMJD2A Inhibitor | 50 mg | 14062 | $225 | Add to Cart |
| 10 mg | 14063 | $70 | Add to Cart | ||
| GSK-J1 (cell impermeable) | JMJD3/UTX Inhibitor | 25 mg | 14068 | $360 | Add to Cart |
| 5 mg | 14069 | $100 | Add to Cart | ||
| GSK-J4 (cell permeable) | JMJD3/UTX Inhibitor | 25 mg | 14070 | $360 | Add to Cart |
| 5 mg | 14071 | $100 | Add to Cart | ||
| IOX1 | JMJD Family Inhibitor | 25 mg | 14056 | $340 | Add to Cart |
| 5 mg | 14057 | $90 | Add to Cart | ||
| JIB-04 | JMJD Family Inhibitor | 25 mg | 14134 | $255 | Add to Cart |
| 5 mg | 14135 | $80 | Add to Cart | ||
| ML-324 | JMJD2 Inhibitor | 25 mg | 14078 | $410 | Add to Cart |
| 5 mg | 14079 | $100 | Add to Cart |
