DNA Methylation

epigenetic modulators of DNA methylation

DNA Methylation is a common epigenetic signaling tool that is is used to control gene expression in eukaryotes. DNA methyltransferase enzymes (DNMTs) catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines. In mammalian cells, DNA methylation is generally associated with gene silencing and effects numerous cellular processes, including embryonic development, genomic imprinting, X-chromosome inactivation and preservation of chromosome stability. Hypermethylation of the promoters of tumor suppressor genes often occur in certain types of cancers.

Active Motif offers several small molecules that can be used to modify DNA methylation levels. Some molecules act as chemical analogs for the nucleoside cytidine that, when incorporated into growing DNA strands, will inhibit the DNMT enzymes that normally methylated DNA. Other compounds act as non-nucleoside DNA methylation inhibitors.

Name Appl. Format Cat No. Price  
2'-Deoxy-5-fluorocytidine DNMT Inhibitor 250 mg 14108 $420 Buy
50 mg 14109 $105 Buy
5-Aza-2'-deoxycytidine (Decitabine) DNMT Inhibitor 50 mg 14100 $425 Buy
10 mg 14101 $120 Buy
5-Azacytidine DNMT Inhibitor 250 mg 14102 $95 Buy
50 mg 14103 $45 Buy
6-Thioguanine DNMT Inhibitor 1 g 14126 $135 Buy
100 mg 14127 $45 Buy
Mithramycin A DNMT1 Inhibitor 5 mg 14128 $170 Buy
1 mg 14129 $55 Buy
RG108 Non-nucleoside DNMT Inhibitor 25 mg 14104 $245 Buy
5 mg 14105 $65 Buy
Sinefungin Methyltransferase Inhibitor 5 mg 14088 Discontinued
1 mg 14089 Discontinued
Zebularine DNMT Inhibitor 25 mg 14106 $275 Buy
5 mg 14107 $85 Buy