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Enabling Epigenetics Research

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  • VIEW ALL PRODUCTS
  • Services
    • Bioinformatic Services
    • Single B-cell Antibody Service
    • Epigenetic Services
      • ChIP-Sequencing (ChIP-Seq) Services
        • FFPE ChIP-Seq
        • Super-Enhancer Profiling
        • HistonePath™ ChIP-Seq Services
        • FactorPath™ ChIP-Seq Services
        • ChIP-Seq Spike-in
        • Pol II ChIP-Seq
      • CUT&Tag-IT® Service
      • ChIC/CUT&RUN Service
      • DNA Methylation Services
        • RRBS (Reduced Representation Bisulfite Sequencing)
        • MeDIP-Sequencing (MeDIP-Seq)
        • hMeDIP-Sequencing (hMeDIP-Seq)
        • Genome-wide 5-fC and 5-caC Profiling
      • ATAC-Seq Services
      • Hi-C Service
      • Single-Cell Services
        • Single-Cell ATAC-Seq (scATAC-Seq) Service
        • Single-Cell and Single-Nucleus RNA-Seq (scRNA-Seq/snRNA-Seq) Service
        • Single-Cell Multiome Service
      • RNA-Seq Service
      • Interactome Profiling (RIME)
      • Mod Spec® Service
      • ChIP Antibody Validation Services
      • ChIP-qPCR Services
  • ChIP Assays
    • ChIP Accessory Products
      • ChIP-IT® qPCR Analysis Kit
      • ChIP-IT® Control Kits
      • ChIP Control qPCR Primer Sets
        • Human Control qPCR Primer Sets
        • Mouse Control qPCR Primer Sets
        • Model Organism Control qPCR Primer Sets
      • ChIP Buffers & Blockers
      • Protein G Agarose & Magnetic Beads
      • Bridging Antibody for Mouse IgG
      • ChIP DNA Purification Kit
    • ChIP Kits
      • ChIP-IT High Sensitivity®
      • ChIP-IT® Express Chromatin Immunoprecipitation Kits
      • ChIP-Seq Spike-In Normalization
      • ChIP-IT® FFPE II
      • ChIP-IT® PBMC
      • enChIP®
      • Low Cell ChIP Kit
      • Low Cell ChIP Optimization Module
      • Tag-ChIP-IT®
      • TAM-ChIP™
      • Specialized ChIP-IT® Kits
        • ChIP-Bis-Seq
        • Re-ChIP-IT®
        • RNA ChIP-IT®
        • ChIP-IT® Express High Throughput
        • ChIP-IT® Express Shearing Kits
    • ChIP-Validated Antibodies
    • Sonicators
    • CUT&Tag-IT® Assay Kits
      • CUT&Tag-IT® Assay Kit - Cells
      • CUT&Tag-IT® Assay Kit - Tissue
      • CUT&Tag-IT® R-loop Assay Kit
      • CUT&Tag-IT® Spike-In Control
    • ChIC/CUT&RUN Assay Kit
  • Chromatin Analysis
    • ATAC-Seq Assay Kits
      • ATAC-Seq Kit
      • Fixed Cell ATAC-Seq Kit
      • Recombinant Transposase Enzymes
      • Nextera™-Compatible Multiplex Primers (96 plex)
    • Histone Analysis
      • Histone Acetyltransferase Activity (HAT)
        • Histone Acetyltransferase Assay Kit (Fluorescent)
      • Histone Deacetylase Activity (HDAC)
        • HDAC Assay Kits
      • Histone Modification ELISAs
        • Total Histone H3 ELISA
        • Histone H3 methylated Lys4 ELISA (H3K4)
        • Histone H3 acetyl Lys9 ELISA (H3K9)
        • Histone H3 methylated Lys9 ELISA (H3K9)
        • Histone H3 acetyl Lys14 ELISA (H3K14)
        • Histone H3 acetyl Lys27 ELISA (H3K27)
        • Histone H3 methylated Lys27 ELISA (H3K27)
        • Histone H3 phospho Ser10 ELISA (H3S10ph)
        • Histone H3 phospho Ser28 ELISA (H3S28ph)
      • Histone Peptide Array
        • MODified™ Histone Peptide Array
      • Histone Purification
        • Histone Purification Kit
        • Histone Purification Mini Kit
        • Histone Extraction Kit
      • Recombinant Histones
    • Nucleosome Analysis
      • NOMe-Seq
      • Recombinant Nucleosomes
      • Nucleosome Assembly Control DNA
      • Nucleosome Preparation Kit
    • Chromatin Assembly Kit
    • Antibodies & Recombinant Proteins
    • Activators / Inhibitors
      • DNA Methylation
      • Histone Acetylation (HAT & HDAC)
      • Histone Methylation (HMT & HDM)
      • Sirtuins (SIRT & Sir2)
  • Antibodies
    • All Antibodies
    • ChIP-Validated Antibodies
    • CUT&Tag-Validated Antibodies
    • CUT&RUN-Validated Antibodies
    • AbFlex® Recombinant Antibodies
    • Histone & Histone Modification Antibodies
    • Chromatin Modifiers
    • DNA Methylation
    • Transcription Factors
    • Antibody Labeling
  • Recombinant Proteins & Enzymes
    • Nucleosomes
    • Histones and Modified Histones
    • Histone Peptides
    • Bromodomains
    • RNA Methylation Enzymes
    • HATs & HDACs
    • HMTs & HDMs
    • Other Recombinant Proteins & Enzymes
      • DNA Damage Proteins
      • Growth Factors
      • Protein Kinases
      • Transcription Factors
      • Ubiquitination
  • Gene Regulation
    • TransAM® Transcription Factor Activation Assays
    • Transcriptional Regulation
    • Post-Transcriptional Regulation
    • Co-IP Kits
  • NGS
    • Next Gen DNA Library Kit
    • YourSeq (FT & 3’DGE) Strand-Specific mRNA Library Prep
  • DNA Methylation
    • DNA Methylation Antibodies
    • DNA Methylation Enzymes
    • Bisulfite Conversion
    • Methylated DNA Enrichment
      • MethylCollector™ MBD Capture Kit
      • Methylated DNA Immunopreciptation (MeDIP) Kit
      • MethylCollector™ Ultra
      • Hydroxymethylated DNA Immunoprecipitation (hMeDIP) Kit
      • Hydroxymethyl Collector™
      • 5hmC Profiling Kit
    • DNA Methylation ELISAs & Other Assays
      • DNA Methyltransferases (DNMT)
        • DNMT Activity / Inhibition Assay
      • Global DNA Methylation Assays
        • Global 5-hmC DNA ELISA Kit
        • Global DNA Methylation Assay–LINE-1
        • Global 5-hmC Quantification Kit
      • Methylated DNA Amplification
      • Methylated DNA Controls
        • Fully Methylated Jurkat DNA
        • Methylated DNA Standard Kit
        • 5-Carboxylcytosine DNA Standard Kit
      • DNA Methylation Products & Services | 5mC, 5hmC, & Other Variants
  • Cell Biology
    • RAS GTPase Products
      • Ras GTPase Chemi ELISA Kit
      • KRAS In-well Lysis ELISA Kit
    • Cell, Acid, & Tissue Extracts
      • Cell Extracts
      • Acid Extracts
      • Tissue Extracts
    • Fluorescence
      • Fluorescent Dyes
        • Fluorescent Chromeo™ Dyes
          • Chromeo™ 488
          • Chromeo™ 494
          • Chromeo™ 505
          • Chromeo™ 546
          • Chromeo™ 642
        • Fluorescent Chromeo™ Py-Dyes
      • Fluorescent Tools for Click Chemistry
        • Chromeo™ Tools for Click Chemistry
      • MAX Stain™ Immunofluorescence Tools
        • MAXblock™ Blocking Medium
        • MAXbind™ Staining Medium
        • MAXwash™ Washing Medium
          • Chromeo™ 488 Tools for STED Microscopy
          • Chromeo™ 505 Tools for STED Microscopy
          • Chromeo™ 494 Tools for STED Microscopy
          • Chromeo™ 488 Tools for GSDIM Microscopy
          • Chromeo™ 505 Tools for GSDIM Microscopy
          • Chromeo™ 546 Tools for GSDIM Microscopy
          • ATTO 532 (GSD) Secondary Antibody Conjugates
          • ATTO 647N (STED/GSD) Secondary Antibody Conjugates
          • Rhodamine 6G (GSD) Secondary Antibody Conjugates
      • Fluorescent Kits for Cell Biology
        • Albumin Blue Fluorescent Assay Kit
        • ToxCount™ Cell Viability Assay
        • ProStain™ Protein & Extract Quantification
    • Transfection & Expression
      • RapidTrans™
      • DNA and miRNA Transfection
      • Chariot™ Protein Delivery Reagent
    • Other Cell Biology Assays
      • Myelin Basic Protein, dephosphorylated
      • Nitric Oxide Quantitation Kit
      • Protein Activity Assays
      • β-Galactosidase Staining Kit
  • Sample Preparation
    • Nuclear Extraction
      • Nuclear Extract Kit
      • Protease Inhibitor Cocktail
      • Phosphatase Inhibitor Cocktail
      • Deacetylase Inhibitor
      • PMSF
    • DNA Purification
      • Chromatin IP DNA Purification
      • Cell-Free DNA (cfDNA) Purification Kit
    • RNA Isolation
      • RNA Subcellular Isolation Kit
      • DNase I Treatment Kit
    • Accessory Products
      • Whole Genome Amplification
        • GenoMatrix™ Whole Genome Amplification Kit
      • ProStain™ Protein Quantification Kit
      • Chromeo™ Antibody Labeling
      • Mitochondrial Fractionation Kit
      • Dounce Homogenizer
  • Sonication Products
    • PIXUL® Multi-Sample Sonicator
    • PIXUL® Kits
    • PIXUL® Labware
    • EpiShear™ Probe Sonicator
    • Probe Sonicator Accessories
    • Polystyrene Sonication Tubes
  • SARS-CoV-2 Products & Kits
    • SARS-CoV-2 Overview & Product Data
    • Recombinant SARS-CoV-2 Antibodies
    • SARS-CoV-2 Spike S1 Protein ELISA Kit
    • Recombinant SARS-CoV-2 Proteins
  • LightSwitch™ Promoter and 3’ UTR Collections
    • LightSwitch™ Promoter & Distal Regulatory Element Luciferase Construct Collection
    • miRNA & 3’ UTR Luciferase Construct Collection
    • LightSwitch Luciferase Reporter Assay System Reagents

Services

  • Bioinformatic Services
  • Single B-cell Antibody Service
  • Epigenetic Services

ChIP Assays

  • ChIP Accessory Products
  • ChIP Kits
  • ChIP-Validated Antibodies
  • Sonicators
  • CUT&Tag-IT® Assay Kits
  • ChIC/CUT&RUN Assay Kit

Chromatin Analysis

  • ATAC-Seq Assay Kits
  • Histone Analysis
  • Nucleosome Analysis
  • Chromatin Assembly Kit
  • Antibodies & Recombinant Proteins
  • Activators / Inhibitors

Antibodies

  • All Antibodies
  • ChIP-Validated Antibodies
  • CUT&Tag-Validated Antibodies
  • CUT&RUN-Validated Antibodies
  • AbFlex® Recombinant Antibodies
  • Histone & Histone Modification Antibodies
  • Chromatin Modifiers
  • DNA Methylation
  • Transcription Factors
  • Antibody Labeling

Recombinant Proteins & Enzymes

  • Nucleosomes
  • Histones and Modified Histones
  • Histone Peptides
  • Bromodomains
  • RNA Methylation Enzymes
  • HATs & HDACs
  • HMTs & HDMs
  • Other Recombinant Proteins & Enzymes

Gene Regulation

  • TransAM® Transcription Factor Activation Assays
  • Transcriptional Regulation
  • Post-Transcriptional Regulation
  • Co-IP Kits

NGS

  • Next Gen DNA Library Kit
  • YourSeq (FT & 3’DGE) Strand-Specific mRNA Library Prep

DNA Methylation

  • DNA Methylation Antibodies
  • DNA Methylation Enzymes
  • Bisulfite Conversion
  • Methylated DNA Enrichment
  • DNA Methylation ELISAs & Other Assays

Cell Biology

  • RAS GTPase Products
  • Cell, Acid, & Tissue Extracts
  • Fluorescence
  • Transfection & Expression
  • Other Cell Biology Assays

Sample Preparation

  • Nuclear Extraction
  • DNA Purification
  • RNA Isolation
  • Accessory Products

Sonication Products

  • PIXUL® Multi-Sample Sonicator
  • PIXUL® Kits
  • PIXUL® Labware
  • EpiShear™ Probe Sonicator
  • Probe Sonicator Accessories
  • Polystyrene Sonication Tubes

SARS-CoV-2 Products & Kits

  • SARS-CoV-2 Overview & Product Data
  • Recombinant SARS-CoV-2 Antibodies
  • SARS-CoV-2 Spike S1 Protein ELISA Kit
  • Recombinant SARS-CoV-2 Proteins

LightSwitch™ Promoter and 3’ UTR Collections

  • LightSwitch™ Promoter & Distal Regulatory Element Luciferase Construct Collection
  • miRNA & 3’ UTR Luciferase Construct Collection
  • LightSwitch Luciferase Reporter Assay System Reagents
▸Search
▾Apply Product Filters▾
  • (814) Antibodies
    • Antibody Type
      • (447) Polyclonal
      • (243) Monoclonal
      • (124) Recombinant
    • Application
      • (723) Western blot
      • (265) Chromatin Immunoprecipitation
      • (254) Immunofluorescence
      • (207) Immunocytochemistry
      • (160) Dot Blot
      • (155) ChIP-Seq
      • (145) Immunoprecipitation
      • (85) Immunohistochemistry
      • (54) ELISA
      • (21) Supershift
      • (18) CUT&Tag
      • (13) CUT&RUN
      • (10) Dot blot
      • (7) Methyl DNA Immunoprecipitation
      • (5) Neutralizing
      • (3) Flow Cytometry
      • More
    • Isotype
      • (377) IgG
      • (146) IgG2a
      • (120) Serum
      • (101) IgG1
      • (31) IgG2b
      • (30) IgG1, k
      • (3) IgG3
      • (2) IgG2c
      • (1) IgG/IgM
      • (1) IgG1k
      • (1) IgG2a, k
      • (1) IgM
      • More
    • Reactivity
      • (715) Human
      • (222) Mouse
      • (221) Wide Range Predicted
      • (36) Not Species Specific
      • (26) Rat
      • (24) Virus
      • (22) Budding Yeast
      • (12) Drosophila
      • (8) Fission Yeast
      • (5) Monkey
      • (3) Bovine
      • (2) Hamster
      • (1) C. elegans
      • (1) Canine
      • (1) Rabbit
      • More
    • Modification
      • (505) None
      • (99) Methylated
      • (65) Phosphorylated
      • (62) Acetylated
      • (2) Biotinylated
      • (2) HA-Tag
      • (2) HRP Conjugated
      • (2) Myc-Tag
      • (2) Ubiquitinated
      • (1) AM-Tag
      • (1) Amide
      • (1) Citrullinated
      • (1) His-Tag
      • (1) Propionylated
      • More
    • Purification
      • (267) Affinity Purified
      • (223) Protein A Chromatography
      • (169) Protein G Chromatography
      • (128) None
      • (13) Ni-NTA
      • (7) Ascites
      • (6) Culture Supernatant
      • (1) IgM purification
      • More
    • Host
      • (464) Rabbit
      • (270) Mouse
      • (60) Rat
      • (18) Human
      • (2) Goat
      • More
    • Product Category
      • (811) Primary Antibodies
      • (2) HRP Secondaries
      • (1) Bridging Antibody
    • Histone Products
      • (133) Histone H3
      • (36) Histone H4
      • (32) Histone H2A
      • (14) Histone H2B
      • (6) Histone H2AZ
      • (5) Histone H1
      • (4) Histone H2AX
      • (2) Histone H2Av
      • More
    • New Products
      • (142) New
    • Sample Available
      • (682) Available
      • (102) Not available
    • Antibody Category
      • (406) Transcriptional Regulation
      • (236) Histones
      • (206) Stem Cells
      • (205) Chromatin Modifiers
      • (98) AbFlex Recombinant Antibodies
      • (77) Cell Biology
      • (58) DNA Methylation
      • (36) Cell Cycle
      • (34) Cell Signaling & Signal Transduction
      • (34) DNA Damage
      • (19) Nuclear Receptors
      • (16) Apoptosis
      • (16) RNA Processing
      • (7) Epitope Tag
      • More
    • Research Area
      • (457) Chromatin & Histones
      • (385) Transcription
      • (193) Methylation
      • (107) Acetylation & Deacetylation
      • (89) Phosphorylation
      • (63) Cell Cycle
      • (50) DNA Damage & Repair
      • (47) Cell Signaling
      • (24) Apoptosis
      • (22) Nuclear Receptors
      • (6) Oxidative Stress
      • (4) Post Transcription
      • (3) Fluorescence
      • (3) Immunoprecipitation
      • (1) ELISAs
      • (1) Ubiquitination
      • More
  • (57) Extracts
    • Extract Type
      • (42) Nuclear
      • (7) Acid
      • (6) Whole-cell
      • (2) Cytoplasmic
    • Extract Species
      • (42) Human
      • (6) Mouse
      • (6) Rat
      • (3) Monkey
    • Treatment
      • (28) Untreated
      • (4) TPA
      • (2) Forskolin
      • (2) H2O2
      • (2) TNF-α
      • (2) TPA + CI
      • (1) Acetaldehyde
      • (1) Anacardic acid
      • (1) Anisomycin
      • (1) CoCl2
      • (1) Colcemid
      • (1) EGF
      • (1) ETO
      • (1) Hypoxia
      • (1) IFNγ
      • (1) IL-1α
      • (1) IL-6
      • (1) PHA
      • (1) PTX
      • (1) Prolactin
      • (1) Retinoic acid
      • (1) Serum
      • (1) Sodium butyrate
      • More
    • Cell Line / Tissue
      • (16) HeLa
      • (4) Hep G2
      • (4) Jurkat
      • (3) COS-7
      • (3) MCF-7
      • (3) PC-12
      • (3) WI-38
      • (2) F9
      • (2) NIH/3T3
      • (2) Nb2
      • (2) THP-1
      • (1) 293
      • (1) A-431
      • (1) C2C12
      • (1) DU 145
      • (1) K-562
      • (1) MDA-MB-231
      • (1) P19
      • (1) PANC-1
      • (1) Raji
      • (1) Rat Liver
      • (1) Saos-2
      • (1) T-47D
      • (1) U-937
      • More
    • Research Area
      • (56) Transcription
      • (7) Chromatin & Histones
    • Histone Products
      • (8) Histone H1
      • (8) Histone H2A
      • (8) Histone H2AX
      • (8) Histone H2AZ
      • (8) Histone H2Av
      • (8) Histone H2B
      • (8) Histone H3
      • (8) Histone H4
      • More
    • Modification
      • (8) Acetylated
      • (8) Methylated
      • (8) None
      • (8) Phosphorylated
  • (22) Fluorescent Dyes
    • Dye Category
      • (11) Chromeo™ Fluorescent Dyes
      • (7) Clickable Fluorophores
      • (4) Chromeo™ Py-Dyes (pyrylium)
      • (4) Fluorescent Labeling Kits
      • (3) Fluorescent Assays
      • More
    • Attachment
      • (8) NHS-Ester
      • (5) Amine
      • (4) Alkyne
      • (3) Azide
      • (1) Albumin
      • (1) Esterase / DNA
      • More
    • Research Area
      • (21) Fluorescence
      • (5) Sample Preparation
      • (2) Cell Cycle
      • (1) Apoptosis
    • Large Stokes Shift
      • (14) No
      • (8) Yes
    • Absorption Range
      • (10) 450-529 nm
      • (7) 530-600 nm
      • (4) 610-700 nm
      • (1) 350-445 nm
    • Emission Range
      • (10) 610-700 nm
      • (9) 535-600 nm
      • (4) 400-530 nm
  • (335) Kits
    • New Products
      • (40) New
    • Product Category
      • (96) Chromatin Immunoprecipitation
      • (46) Phospho-protein Detection
      • (42) Transcription Factor ELISAs
      • (35) Epigenetic Services
      • (34) Sample Preparation
      • (14) DNA Methylation
      • (12) Histone ELISAs
      • (10) Gelshift / Supershift
      • (8) Histone Assays
      • (7) Antibody Labeling
      • (7) Chromatin
      • (4) Co-Immunoprecipitation
      • (4) Immunofluorescence
      • (4) Library Prep
      • (3) Histone Array
      • (3) Ras GTPase
      • (2) Chromatin Assembly
      • (1) Nitric Oxide Assays
      • (1) Protein Delivery
      • (1) Sandwich ELISAs
      • (1) miRNA Target Validation
      • More
    • Research Area
      • (182) Chromatin & Histones
      • (118) Transcription
      • (99) Immunoprecipitation
      • (97) ELISAs
      • (91) Accessories
      • (79) Sample Preparation
      • (76) Phosphorylation
      • (59) Cell Signaling
      • (52) Methylation
      • (20) Apoptosis
      • (19) Cell Cycle
      • (16) Sonication
      • (15) Acetylation & Deacetylation
      • (10) DNA Damage & Repair
      • (8) Fluorescence
      • (3) Nuclear Receptors
      • (3) Oxidative Stress
      • (2) Gene Regulation
      • (1) Clinical Research
      • (1) DNA Methylation
      • (1) Histone Post Translational Modifications
      • (1) Post Transcription
      • More
    • Histone Products
      • (23) Histone H3
      • (11) Histone H4
      • (10) Histone H2A
      • (10) Histone H2B
      • (1) Histone H1
      • (1) Histone H2AX
      • (1) Histone H2AZ
      • (1) Histone H2Av
      • More
    • Modification
      • (9) None
      • (7) Methylated
      • (4) Acetylated
      • (3) Phosphorylated
      • (2) Biotinylated
      • More
  • (748) Recombinant Proteins
    • New Products
      • (396) New
    • Protein Category
      • (202) Histone
      • (165) Transcription
      • (109) Kinase
      • (65) Histone Methyltransferase (HMT)
      • (45) Bromodomain
      • (26) Histone Deacetylase (HDAC)
      • (25) DNA Damage
      • (21) Histone Demethylase (HDM)
      • (17) Nuclear Receptor
      • (15) DNA Methyltransferase (DNMT)
      • (12) Histone Acetyltransferase (HAT)
      • (6) Growth Factor
      • (5) Cytosine Oxygenase (TET)
      • (1) Glucosyltransferase
      • (1) Neddylation
      • (1) Poly ADP-ribosylation
      • (1) Ubiquitination
      • More
    • Expressed In
      • (398) E. coli
      • (311) Baculovirus
      • (30) Synthetic
      • (3) E. coli / Synthetic
      • (2) 293 cells
      • (1) Bovine
      • (1) Sf9 cells
      • More
    • Protein Species
      • (652) Human
      • (34) Xenopus
      • (25) N/A
      • (10) SARS-CoV-2
      • (3) S. pyogenes
      • (3) Virus
      • (2) Drosophila melanogaster
      • (2) E. coli
      • (2) Mouse
      • (2) S. aureus
      • (1) Bovine
      • (1) Escherichia virus T4
      • (1) Hunan
      • (1) L. mesenteroides
      • (1) Naegleria
      • (1) Proteus vulgaris
      • (1) Viral
      • More
    • Modification
      • (290) FLAG-Tag
      • (157) His-Tag
      • (79) Methylated
      • (66) Biotinylated
      • (63) None
      • (57) GST-Tag
      • (16) Acetylated
      • (4) Phosphorylated
      • More
    • Research Area
      • (391) Chromatin & Histones
      • (226) Methylation
      • (208) Transcription
      • (119) Phosphorylation
      • (117) Acetylation & Deacetylation
      • (117) Cell Signaling
      • (32) Cell Cycle
      • (29) Post Transcription
      • (19) DNA Damage & Repair
      • (19) Nuclear Receptors
      • (12) Apoptosis
      • (10) Oxidative Stress
      • (3) Ubiquitination
      • (2) Sample Preparation
      • More
    • Histone Products
      • (169) Histone H3
      • (20) Histone H4
      • (13) Histone H2A
      • (11) Histone H2B
      • (3) Histone H1
      • (3) Histone H2AZ
      • (2) Histone H2AX
      • More
  • (145) Reporter Assays
    • LightSwitch™ Collections
      • (11) Validated Pathway Assays
      • (8) Stable Cell Lines
      • (6) lncRNA Promoter Reporters
      • (1) 3´UTR Reporters
      • (1) Promoter Reporters
      • More
    • Product Category
      • (92) Synthetic Response Elements
      • (11) Pathway Biomarker Sets
      • (8) LightSwitch™ 3´UTR Controls
      • (8) LightSwitch™ Promoter Controls
      • (8) LightSwitch™ Reporter Collections
      • (8) Stable Reporter Cell Lines
      • (4) LightSwitch™ Empty Vectors
      • (2) Transfection Reagents
      • (2) miRNA Mimics and Inhibitors
      • (1) LightSwitch™ Assay Kits
      • (1) Synthetic miRNA Targets
      • More
    • Research Area
      • (132) Transcription
      • (16) Post Transcription
      • (3) Apoptosis
      • (3) DNA Damage & Repair
      • (1) Nuclear Receptors
      • More
    • miRNA Products
      • (1) miRNA Inhibitors
      • (1) miRNA Mimics
      • (1) miRNA Targets
    • Type of Control
      • (8) Negative control
      • (8) Positive control
      • (4) Empty vector
      • (1) Stable HT1080 Reporter Cells
      • (1) Stable Hep G2 Reporter Cells
      • More
  • (69) Small Molecules
    • New Products
      • (1) New
    • Application
      • (27) Histone Acetylation (HAT & HDAC)
      • (16) Histone Methylation (HMT & HDM)
      • (10) Sirtuins
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    • Epigenetics 101
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      • DNA Damage and Mutations Causing Problems? Don’t Get Even, Get MADDD-Seq!
      • Kacme – A New Histone H4 Modification Delivers Non-Mutually Exclusive Histone Acetylation and Methylation
      • Focus on 5hmC: History, Detection, and Applications
      • Shifting the Paradigm – The Critical Role of Transcription Factor Interactions with RNA
      • RNA and DNA Methylation Crosstalk – Regulating Transposable Elements AND Cell Fate!
      • Epigenetic Reprogramming Reverses Age-related Alterations
      • DNA Methylation’s Impact on cfDNA Fragmentation – Considerations When Choosing Biomarkers
      • Coffee, Tea, and CpG....does your favorite beverage affect DNA Methylation?
      • DISCOVER-Seq Tracks Off-target CRISPR/Cas-Gene Editing
      • Keeping Up to Date with KRAS-driven Cancer
      • RIBOTACs - Converting Functional Yet Silent Binders into Potent RNA Degraders
      • Reverse Transcribe and Tagment (RT&Tag): A Novel Technique to Explore Chromatin-Associated RNA
      • Aberrant R-loops in Innate Immunity: Friend and Foe?
      • The Intertwined Lives of SIRT6, DNA Damage Repair, and Longevity
      • LINE-1 Transposable Elements: Can they Provide Liquid Biopsy Biomarkers for Early Cancer Detection and Management?
      • Strategies for KRAS Research and Drug Discovery
      • Early Environmental Exposome Synergizes with Later Dietary Choices to Impact Metabolism
      • African Turquoise Killifish – A Colorful Up-and-Coming Model in Aging Research!
      • Early-life Exposome Accelerates Epigenetic Aging – Is There No Going Back Now?
      • DNA Methylation and Aging: Best of Friends, Worst of Enemies?
      • DNA Methylation for Predicting Prostate Cancer: Where Do We Stand?
      • The Bugs in the Bees Impact Epigenetic Mechanisms to Keep Things Social
      • Mass Spectroscopy Profiling of Histone Modifications
      • Inflammaging – What Epigenetic Associations with Kidney Health Can Tells Us
      • Single-Cell DNA Methylation Sequencing: Small Scale Differences Explain Big Effects!
      • LINE-1 Elements: Walk the LINE-1
      • Proteomics and Epigenetics – Two Worlds Collide to Describe Disease-Related Mechanisms
      • Seeing the Bigger Picture – Spatially Resolving Chromatin Modification Profiles with Spatial-CUT&Tag
      • DNA Modifications Reveal the Splendor of the Plant Epigenetic Landscape
      • ABBS – A Novel Method to Map DNA Methylation Genome-Wide at Base Resolution
      • 3’-Digital Gene Expression (3’-DGE) Sequencing: High Through-put at Low Cost
      • Could Long-term, Partial Reprogramming of our Cells Battle Aging and Give us “Good Genes”?
      • Undruggable No More – Advances for Targeting Mutant Ras Proteins and Cancer
      • Microbiome-induced Epigenetic Changes – Guardians Against Inflammation
      • PROTAC-mediated Targeted Protein Degradation in Cancer: PARP, EGFR, and SMARCAs in Focus
      • Life in the FASTQ Lane
      • Multiomic Epigenetic Analysis Turns Short Stories into Epic Tales
      • Epigenetic Keys Unlock Secrets of the Heart
      • An Epigenetic Link Helps the Gut Microbiome to Battle Obesity
      • Library QC for ATAC-Seq and CUT&Tag
      • RNA Methylation Keeps R-loops Under Control to Maintain Genome Integrity
      • DNA Methylation in Cell-free DNA (cfDNA)
      • Stem Cell Exhaustion: How Metabolism and Epigenetics Impact Stem Cell Aging
      • Alzheimer’s Disease: The Impact of Gut Bacteria and Hippocampal DNA Methylation
      • Oncohistones – Epigenetic Drivers in Cancer
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      • Guide to Single-Cell RNA-Seq
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      • Epigenetics News | February 2020
      • 2020 International Day of Women and Girls in Science
      • Complete Sonication Guide
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      • Epigenetics News | December 2019
      • Role of Lamin A/C Acetylation in Nuclear Architecture
      • Hypoxia Research Wins Nobel Prize
      • Reversing Epigenetic Age
      • 50 Years of Eukaryotic Transcription
      • Past, Present, & Future of Epigenetics
      • Antibody-Guided Tagmentation Methods
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      • Discussing Spatial Organization of the Genome with Dr. Wendy Bickmore
      • Epigenetics of Renal Cell Carcinoma
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      • Discussing Heterochromatin with Dr. Gary Karpen
      • Can RNA & Epigenetics Save Honey Bees?
      • Epigenetics News - May 2019
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      • Epigenetics News - April 2019
      • Guide to Generating the Best ChIP Data
      • Epigenetics News - March 2019
      • Targeting Epigenetic Enzymes
      • Total Epigenome of the Heart
      • International Day of Women and Girls in Science
      • Epigenetics News - February 2019
      • Top Epigenetics Breakthroughs of 2018
      • San Diego Chromatin Club
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      • H3K79 Methylation, DOT1L, and FOXG1 in Neural Development (Tanja Vogel)
      • Contribution of Estrogen Receptor to Breast Cancer Progression (Jason Carroll)
      • Inheritance of Transcriptional Memory by Mitotic Bookmarking (Sheila Teves)
      • Differential Methylated Regions in Autism Spectrum Disorders (Janine La Salle)
      • DNA Damage in Longevity and Ageing (Björn Schumacher)
      • The Impact of Chromatin Modifiers on Disease Development and Progression (Capucine van Rechem)
      • Long-Range Transcriptional Control by 3D Chromosome Structure (Luca Giorgetti)
      • Transgenerational Inheritance and Epigenetic Imprinting in Plants (Mary Gehring)
      • When is a Peak a Peak? (Claudio Cantù)
      • Analysis of 3D Chromatin Structure Using Super-Resolution Imaging (Alistair Boettiger)
      • Gene Dosage Alterations in Evolution and Ageing (Claudia Keller Valsecchi)
      • Structural Analysis of Nucleosomes During Transcription (Lucas Farnung)
      • DNA Methylation Alterations in Neurodegenerative Diseases (Paula Desplats)
      • scDamID, EpiDamID and Lamina Associated Domains (Jop Kind)
      • Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon)
      • Epigenetic Landscapes During Cancer (Luciano Di Croce)
      • Formation of CenH3-deficient Kinetochores (Ines Drinnenberg)
      • Effects of Environmental Cues on the Epigenome and Longevity (Paul Shiels)
      • The Epigenetics of Human Sperm Cells (Sarah Kimmins)
      • Transgenerational Inheritance and Evolution of Epimutations (Peter Sarkies)
      • Transcription Elongation Control by the Paf1 Complex (Karen Arndt)
      • Molecular Mechanisms of Chromatin Modifying Enzymes (Karim-Jean Armache)
      • The Role of PHF13 in Chromatin and Transcription (Sarah Kinkley)
      • Genome Organization Mediated by RNA Polymerase II (Argyrys Papantonis)
      • The Role of Pioneer Factors Zelda and Grainyhead at the Maternal-to-Zygotic Transition (Melissa Harrison)
      • Epigenetics in Human Malaria Parasites (Elena Gómez-Diaz)
      • Bioinformatic Analysis in Epigenetics Research (Nick Pervolarakis)
      • Anchor-Based Bisulfite Sequencing (Ben Delatte)
      • Enhancer Communities in Adipocyte Differentiation (Susanne Mandrup)
      • Transposable Elements in Gene Regulation and Evolution (Marco Trizzino)
      • Hydroxymethylation Landscape in Immune Cells (Marcela Sjöberg)
      • Single Cell Epigenomics in Neuronal Development (Tim Petros)
      • Oncohistones as Drivers of Pediatric Brain Tumors (Nada Jabado)
      • Characterization of Epigenetic States in the Oligodendrocyte Lineage (Gonçalo Castelo-Branco)
      • Multiple challenges of ATAC-Seq, Points to Consider (Yuan Xue)
      • The Effect of lncRNAs on Chromatin and Gene Regulation (John Rinn)
      • Epigenetic Clocks and Biomarkers of Ageing (Morgan Levine)
      • Epigenetic and Metabolic Regulation of Early Development (Jan Żylicz)
      • Multiple challenges of CUT&Tag (Cassidee McDonough, Kyle Tanguay)
      • The Role of Histone Dopaminylation and Serotinylation in Neuronal Plasticity (Ian Maze)
      • The Role of Blimp-1 in Immune-Cell Differentiation (Erna Magnúsdóttir)
      • Multimodal Characterization of Cellular Identity | CITE-Seq and Beyond (Peter Smibert, VP of 10X Genomics)
      • The Effect of Mechanotransduction on Chromatin Structure and Transcription in Stem Cells (Sara Wickström)
      • Single-Cell Technologies using Microfluidics (Ben Hindson, CSO of 10x Genomics)
      • Epigenome-based Precision Medicine (Eleni Tomazou)
      • Epigenetics and Epitranscriptomics in Cancer (Manel Esteller)
      • Enhancer-Promoter Interactions During Development (Yad Ghavi-Helm)
      • The Effect of Vitamin D on the Epigenome (Folami Ideraabdullah)
      • H3K4me3, SET Proteins, Isw1, and their Role in Transcription (Jane Mellor)
      • The Role of DNA Methylation in Epilepsy (Katja Kobow)
      • MacroH2A Function in Development and Disease (Emily Bernstein)
      • Spatio-Temporal Alterations in Chromosome Dynamics (Jane Skok)
      • Chromatin Organization During Development and Disease (Marieke Oudelaar)
      • Enhancers and Chromatin Remodeling in Mammary Gland Development (Camila dos Santos)
      • The Role of SMCHD1 in Development and Disease (Marnie Blewitt)
      • Single-Molecule Imaging of the Epigenome (Efrat Shema)
      • Heterochromatin Protein 1 and its Influence on the Structure of Chromatin (Serena Sanulli)
      • The Effects of Early Life Stress on Mammalian Development (Catherine J. Peña)
      • Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard)
      • Effects of Non-Enzymatic Covalent Histone Modifications on Chromatin (Yael David)
      • ATAC-Seq, scATAC-Seq and Chromatin Dynamics in Single-Cells (Jason Buenrostro)
      • Synthetic Chromatin Epigenetics (Karmella Haynes)
      • Development of Integrative Machine Learning Tools for Neurodegenerative Diseases (Enrico Glaab)
      • Ultraconserved Enhancers and Enhancer Redundancy (Diane Dickel)
      • Sandra Hake headshot Variants of Core Histones: Modulators of Chromatin Structure and Function (Sandra Hake)
      • DNA Methylation and Mammalian Development (Déborah Bourc'his)
      • Chromatin Analysis using Mass Spectrometry (Axel Imhof)
      • Chromatin Profiling: From ChIP to CUT&RUN, CUT&Tag and CUTAC (Steven Henikoff)
      • Effects of DNA Methylation on Diabetes (Charlotte Ling)
      • Nutriepigenetics: The Effects of Diet on Behavior (Monica Dus)
      • Investigating the Dynamics of Epigenetic Plasticity in Cancer with Single Cell Technologies (Céline Vallot)
      • Epigenetic Regulation of Stem Cell Self-Renewal and Differentiation (Peggy Goodell)
      • Genome-Wide Investigation of Epigenetic Marks and Nucleosome Positioning (Keji Zhao)
      • The Role of lncRNAs in Tumor Growth and Treatment (Sarah Diermeier)
      • Unraveling Mechanisms of Chromosome Formation (Job Dekker)
      • Transcription and Polycomb in Inheritance and Disease (Danny Reinberg)
      • The Epigenetics of COVID-19 (Sandra Atlante & Carlo Gaetano)
      • Epigenetic Reprogramming During Mammalian Development (Wolf Reik)
      • In Vivo Nucleosome Structure and Dynamics (Srinivas Ramachandran)
      • Pioneer Transcription Factors and Their Influence on Chromatin Structure (Ken Zaret)
      • The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi)
      • Development of Site-Specific ChIP Technologies (Hodaka Fujii)
      • Regulation of Chromatin Organization by Histone Chaperones (Geneviève Almouzni)
      • How the "Fragile Nucleosome" Science Community Came to Life (Christine Cucinotta, Melvin Noe Gonzalez)
      • Epigenetic Influence on Memory Formation and Inheritance (Isabelle Mansuy)
      • Influence of Dynamic RNA Methylation on Gene Expression (Chuan He)
      • How to Publish in Nature: Lessons from the ENCODE Consortium (Michelle Trenkmann, Senior Editor at Nature)
      • The Role of Non-Histone Proteins in Chromosome Structure and Function During Mitosis (Bill Earnshaw)
      • Effects of DNA Methylation on Chromatin Structure and Transcription (Dirk Schübeler)
      • CpG Islands, DNA Methylation, and Disease (Sir Adrian Bird)
      • Biophysical Modeling of 3-D Genome Organization (Leonid Mirny)
      • From Nucleosome Structure to Function (Karolin Luger)
      • Identification of Functional Elements in the Genome (Bing Ren)
      • Hi-C and Three-Dimensional Genome Sequencing (Erez Lieberman Aiden)
      • Chromatin Structure and Dynamics at Ribosomal RNA Genes (Tom Moss)
      • Epigenetic Origins Of Heterogeneity And Disease (Andrew Pospisilik)
      • PIXUL: On the Leading Edge of Chromatin Shearing (Karol Bomsztyk and Tom Matula)
      • Influence of Histone Variants on Chromatin Structure and Metabolism (Marcus Buschbeck)
      • Epigenetic Mechanisms of Aging and Longevity (Shelley Berger)
      • Epigenetics & Glioblastoma: New Approaches to Treat Brain Cancer (Lucy Stead)
      • The Past, Present, and Future of Epigenetics (Joe Fernandez, founder of Active Motif)
      • The Interchromatin Network Model (Ana Pombo)
      • Dosage Compensation in Drosophila (Asifa Akhtar)
      • Spatial Organization of the Human Genome (Wendy Bickmore)
      • Heterochromatin and Phase Separation (Gary Karpen)
      • Diabetes and Epigenetics (Jean-Sébastien Annicotte)
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      • Cancer and Epigenetics (David Jones)
      • The Nucleosome: From Atoms to Genomes (Ada and Don Olins)
      • Multiple Challenges in ChIP (Adam Blattler)
      • Function of Insulators in 3D Genome Folding (Maria Gambetta)
    • Epigenetics eBooks
      • CUT&RUN Complete Guide
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    • Watch Webinars
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      • [VIDEOS] Chromatin-Con 2023: Epigenetics of Aging Meeting
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      • [WEBINAR] Anchor-Based Bisulfite Sequencing (ABBS) Determines Genome-wide DNA Methylation
      • [WEBINAR] Novel Translational CUT&Tag Assays
      • [VIDEOS] Chromatin-Con: 2021 Epigenetic Mechanisms & Human Disease Meeting
      • [WEBINAR] Improved Chromatin Analysis with CUT&Tag Assays
      • [WEBINAR] Utilizing Single-cell Workflows for Clinical Multiomics Analysis
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    • Download Scientific Posters
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      • [Poster] Epigenetics of Aging
      • [Poster] Epi-Seq: High-Throughput Epigenomic Mapping
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Publications

Protocols

As the epigenetics experts, Active Motif continues to develop new methods and helpful techniques to support your research. Our goal is to ensure your success with everything from gold standard assays to emerging approaches for epigenetics analysis. Check back often as we add new protocols, technotes and guides to this resource.

Supplemental Protocols

  • Supplemental Protocol: Yeast Lysis with PIXUL® Multi-Sample Sonicator
  • Supplemental Protocol: Bacterial Lysis with PIXUL® Multi-Sample Sonicator
  • ChIP-IT® Express: Supplemental Protocol for Suspension Cells

TechNotes

  • TechNote: Sonication Recommendations for ChIP
  • TechNote: Sonicating Limited Tissue Samples with PIXUL® Multi-Sample Sonicator for ChIP-Seq Analysis
  • TechNote: Sample Preparation for Proteomics Applications with PIXUL Multi-Sample Sonicator

Quick Guides

  • Quick Guide: PIXUL® Multi-Sample Sonicator
  • Quick Guide: Shearing Chromatin from Frozen Tissues with PIXUL®
  • Quick Guide-PIXUL® Chromatin Input Preparation Kit
  • Quick Guide-PIXUL® Chromatin Shearing Kit
  • Quick Guide-PIXUL® gDNA Shearing Kit

Other protocols

  • Preparation of Nuclear Extract Using High Salt and Sonication
  • Tn5 Loading Protocol
  • pA-Tn5 Loading Protocol
  • Tagmentation Test Protocol Tn5 or pA-Tn5

Featured Manuals

  • ATAC-Seq Kit
  • CUT&Tag-IT® Assay Kit for Cells
  • CUT&Tag-IT® Assay Kit for Cells - Anti-Mouse
  • CUT&Tag-IT® Assay Kit - Tissue
  • ChIP-IT High Sensitivity® Kit
  • KRAS In-well Lysis ELISA Kit
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