Your Cart
Products
-
Custom Services
- Epigenetic Services
- Custom LightSwitch™ Services
- Hybridoma Conversion to Recombinant Antibody Services
- Functional Genomics - LightSwitch™
- Gene Regulation
-
Epigenetics & Chromatin
- Chromatin Assembly
-
Chromatin Immunoprecipitation
- ChIP Sonicators
- ChIP validated Antibodies
- ChIP-IT® Express Chromatin Immunoprecipitation Kits
- ChIP-IT High Sensitivity®
- ChIP-IT® FFPE II
- ChIP-IT® PBMC
- enChIP®
- Low Cell ChIP-Seq
- Low Cell ChIP-Seq Optimization Module
- Tag-ChIP-IT®
- TAM-ChIP™
- Specialized ChIP-IT® Kits
- ChIP Accessory Products
- ChIP DNA Purification Kit
- NGS Library Preparation
-
DNA Methylation & Enrichment
- DNA Methylation Antibodies & Enzymes
- Bisulfite Conversion Kits & Epigenetic Services
- Methylated DNA Enrichment
- Quantitative DNA Methylation Assays
-
Histone Analysis
- Histone Acetyltransferase Activity (HAT)
- Histone Deacetylase Activity (HDAC)
-
Histone Modification ELISAs
- Total Histone H3 ELISA
- Histone H3 methylated Lys4 ELISA (H3K4)
- Histone H3 acetyl Lys9 ELISA (H3K9)
- Histone H3 methylated Lys9 ELISA (H3K9)
- Histone H3 acetyl Lys14 ELISA (H3K14)
- Histone H3 acetyl Lys27 ELISA (H3K27)
- Histone H3 methylated Lys27 ELISA (H3K27)
- Histone H3 phospho Ser10 ELISA (H3S10ph)
- Histone H3 phospho Ser28 ELISA (H3S28ph)
- Histone Peptide Array
- Histone Purification
- Recombinant Histones
- Nucleosome Analysis
- Activators / Inhibitors
-
Antibodies
- Search/Browse All Antibodies
- Primary Antibodies
- AbFlex® Recombinant Antibodies
- Bridging Antibody
- ChIP Validated Antibodies
- ChIP-Seq Validated Antibodies
- Chromatin Modifying Protein Antibodies
- DNA Methylation Antibodies
- Histone and Histone Modification Antibodies
- Secondary Antibody Conjugates
- Transcription Factor Antibodies
- Antibody Labeling
-
Recombinant Proteins & Enzymes
- Recombinant Proteins
- DNA Damage Proteins
- Growth Factors
- Recombinant Nucleosomes
- Histones and Modified Histones
- Histone Peptides
- Bromodomain Proteins
- RNA Methylation
- Histone Acetyltransferases (HATs) and Histone Deacetylases (HDACs)
- Histone Methyltransferases (HMTs) and Histone Demethylases (HDMs)
- Protein Kinases
- Transcription Factors
- Ubiquitination
- Protein Detection and Quantitation
- Cell, Acid & Tissue Extracts
- Fluorescence
- Sample Preparation
- Transfection & Expression
- Bioinformatics
- Epigenetic Services
- Custom LightSwitch™ Services
- Hybridoma Conversion to Recombinant Antibody Services
- Chromatin Assembly
- Chromatin Immunoprecipitation
- DNA Methylation & Enrichment
- Histone Analysis
- Nucleosome Analysis
- Activators / Inhibitors
- Search/Browse All Antibodies
- Primary Antibodies
- AbFlex® Recombinant Antibodies
- Bridging Antibody
- ChIP Validated Antibodies
- ChIP-Seq Validated Antibodies
- Chromatin Modifying Protein Antibodies
- DNA Methylation Antibodies
- Histone and Histone Modification Antibodies
- Secondary Antibody Conjugates
- Transcription Factor Antibodies
Recombinant Proteins & Enzymes
- Recombinant Proteins
- DNA Damage Proteins
- Growth Factors
- Recombinant Nucleosomes
- Histones and Modified Histones
- Histone Peptides
- Bromodomain Proteins
- RNA Methylation
- Histone Acetyltransferases (HATs) and Histone Deacetylases (HDACs)
- Histone Methyltransferases (HMTs) and Histone Demethylases (HDMs)
- Protein Kinases
- Transcription Factors
- Ubiquitination
- Fluorescent Dyes and Antibodies
- Fluorescent Tools for Click Chemistry
- MAX Stain™ Immunofluorescence Tools
- Super-Resolution Fluorescence Microscopy
- Fluorescent Kits for Cell Biology
-
(870)
Antibodies
- Antibody Type
- Application
- Isotype
- Reactivity
- Modification
- Purification
- Host
- Product Category
- Histone Products
- New Products
- Sample Available
- Antibody Category
-
Research Area
- (463) Chromatin & Histones
- (426) Transcription
- (178) Methylation
- (103) Acetylation & Deacetylation
- (101) Phosphorylation
- (78) Cell Cycle
- (71) DNA Damage & Repair
- (68) Cell Signaling
- (43) Apoptosis
- (21) Nuclear Receptors
- (18) Fluorescence
- (6) Oxidative Stress
- (4) Post Transcription
- (3) Immunoprecipitation
- (1) ELISAs
- (1) SUMOylation
- (1) Ubiquitination
- More
-
(99)
Extracts
- Extract Type
- Extract Species
-
Treatment
- (62) Untreated
- (6) TPA
- (3) IL-6
- (2) Forskolin
- (2) H2O2
- (2) Serum
- (2) TNF-α
- (2) TPA + CI
- (1) Acetaldehyde
- (1) Anacardic acid
- (1) Anisomycin
- (1) CoCl2
- (1) Colcemid
- (1) EGF
- (1) Estradiol
- (1) Etoposide
- (1) Heat shock
- (1) Hypoxia
- (1) IFNγ
- (1) IL-1α
- (1) PHA
- (1) Paclitaxel
- (1) Prolactin
- (1) Retinoic acid
- (1) Sodium butyrate
- (1) Testosterone
- More
-
Cell Line / Tissue
- (18) HeLa
- (7) Hep G2
- (6) Jurkat
- (4) MCF-7
- (4) PC-12
- (3) COS-7
- (3) NIH/3T3
- (3) U-937
- (3) WI-38
- (2) A-431
- (2) C2C12
- (2) F9
- (2) K-562
- (2) LNCaP
- (2) Nb2
- (2) SL-2
- (2) T-47D
- (2) THP-1
- (1) 293
- (1) 3T3-L1
- (1) CCRM-CEM
- (1) Caco-2
- (1) DU 145
- (1) HL-60
- (1) HT-29
- (1) Human Heart
- (1) Human Liver
- (1) Human Lung
- (1) JEG-3
- (1) KG-1
- (1) LoVo
- (1) MDA-MB-231
- (1) MG-63
- (1) MIA PaCa-2
- (1) Mouse Brain
- (1) NIH:OVCAR-3
- (1) P19
- (1) PANC-1
- (1) PC-03
- (1) Raji
- (1) Rat Brain
- (1) Rat Liver
- (1) SK-N-BE
- (1) SW48
- (1) Saos-2
- (1) U-87
- (1) Y-79
- (1) ZR-75-1
- More
- Research Area
- Histone Products
- Modification
- (25) Fluorescent Dyes
-
(326)
Kits
- New Products
-
Product Category
- (94) Chromatin Immunoprecipitation
- (48) Phospho-protein Detection
- (44) Transcription Factor ELISAs
- (42) Sample Preparation
- (25) Epigenetic Services
- (14) DNA Methylation
- (14) Histone ELISAs
- (10) Gelshift / Supershift
- (8) Histone Assays
- (7) Antibody Labeling
- (4) Co-Immunoprecipitation
- (4) Immunofluorescence
- (3) Histone Array
- (2) Chromatin Assembly
- (2) Mitosis Assays
- (1) Nitric Oxide Assays
- (1) Nucleosomes
- (1) Protein Delivery
- (1) Ras GTPase
- (1) miRNA Target Validation
- More
-
Research Area
- (176) Chromatin & Histones
- (114) Transcription
- (102) ELISAs
- (100) Immunoprecipitation
- (93) Accessories
- (78) Sample Preparation
- (77) Phosphorylation
- (60) Cell Signaling
- (48) Methylation
- (23) Cell Cycle
- (20) Apoptosis
- (16) Acetylation & Deacetylation
- (15) Sonication
- (10) DNA Damage & Repair
- (8) Fluorescence
- (3) Nuclear Receptors
- (3) Oxidative Stress
- (2) Gene Regulation
- (1) Clinical Research
- (1) DNA Methylation
- (1) Histone Post Translational Modifications
- (1) Post Transcription
- More
- Histone Products
- Modification
- Product Class
-
(586)
Recombinant Proteins
- New Products
-
Protein Category
- (191) Histone
- (155) Transcription
- (57) Bromodomain
- (55) Histone Methyltransferase (HMT)
- (25) Kinase
- (24) Histone Deacetylase (HDAC)
- (20) Histone Demethylase (HDM)
- (18) DNA Damage
- (16) Nuclear Receptor
- (10) Histone Acetyltransferase (HAT)
- (9) DNA Methyltransferase (DNMT)
- (5) Cytosine Oxygenase (TET)
- (1) Glucosyltransferase
- (1) Neddylation
- (1) Ubiquitination
- More
- Expressed In
- Protein Species
- Modification
-
Research Area
- (374) Chromatin & Histones
- (238) Methylation
- (198) Transcription
- (125) Acetylation & Deacetylation
- (43) Phosphorylation
- (39) Cell Signaling
- (25) Post Transcription
- (21) Cell Cycle
- (16) Nuclear Receptors
- (14) DNA Damage & Repair
- (12) Oxidative Stress
- (9) Apoptosis
- (3) Ubiquitination
- (2) Sample Preparation
- More
- Histone Products
-
(149)
Reporter Assays
- LightSwitch™ Collections
-
Product Category
- (92) Synthetic Response Elements
- (11) Pathway Biomarker Sets
- (8) LightSwitch™ 3´UTR Controls
- (8) LightSwitch™ Promoter Controls
- (8) LightSwitch™ Reporter Collections
- (8) Stable Reporter Cell Lines
- (4) LightSwitch™ Empty Vectors
- (3) Gene Regulation Services
- (3) Transfection Reagents
- (2) miRNA Mimics and Inhibitors
- (1) LightSwitch™ Assay Kits
- (1) Synthetic miRNA Targets
- More
- Research Area
- miRNA Products
- Type of Control
- (59) Small Molecules
MicroRNAs in Cancer eBook | Guide to Studying miRNAs and Performing Screens
MicroRNAs in Cancer eBook
Guide to Studying miRNAs and Performing Screens
The rapid advancements in microRNA (miRNA) research requires new experimental tools to enable scientists to accurately study the role of miRNAs in cancer and other diseases. This MicroRNAs in Cancer eBook summarizes the current miRNA research approaches and outlines how to design and execute an miRNA target screen.
This eBook covers the following topics:
- Introduction to miRNAs and cancer
- Experimental approaches for analyzing miRNAs
- Performing high-throughput miRNA screens
- Case study involving a genome-wide screen to identify new targets of miR-122
Roles of miRNAs in Cancer Biology
MicroRNAs (miRNAs) are an abundant class of small non-coding RNAs that are important regulators of gene expression. miRNAs play a role in numerous biological processes such as cellular signaling, cell differentiation, development, and apoptosis. Mutations and improper regulation of miRNAs have been linked to a variety of physiological disorders such as cancer and heart disease. The emergence of miRNAs has been one of the defining developments in cancer biology over the past decade.
Stay abreast of the
latest developments in
epigenetics research
