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Chromatin Immunoprecipitation (ChIP) Resource Center
Introduction
The chromatin immunoprecipitation (ChIP) assay is the gold standard technique to analyze the binding of transcription factors and cofactors to DNA and the localization of histones and histone modifications throughout the genome.
Chromatin immunoprecipitation protocols involve a multi-step process where each step is of crucial importance to obtain interpretable and reproducible ChIP results that can be trusted. Furthermore, ChIP assays generally require a relatively high amount of starting material, which is difficult to obtain for some sample types. Although the read-out for ChIP-Seq assays has become more efficient as a result of improvements to next-generation sequencing technology in recent years, the core principles of the chromatin immunoprecipitation protocol itself have not significantly evolved since it was first developed over 30 years ago.
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Support
Webinars
- Chromatin Immunoprecipitation (ChIP) Workshop: Optimize Your Pulldowns
- Recent Technology Advances in Epigenomic Profiling
- CUT&Tag vs ChIP-Seq – From Data Generation to Analysis
- Ensuring ChIP-Seq Success
- Advances in ChIP-based Technologies for Profiling Epigenomic Landscapes and Gene Regulatory Networks
- Advanced ChIP-Seq Normalization & Data Analysis Strategies
- Getting Reliable ChIP Data From Difficult Samples
- Bridging ChIP-Seq and Translational Research with PIXUL® Sonication
eBooks
Blogs
- FloChIP: A Quick and Easy ChIP-Seq Technique That Makes Epigenetics Go with the Flow
- Complete Guide to Sonication of Chromatin for ChIP Assays
- Guide to Generating the Best ChIP Data
Podcasts
- Comparing CUT&Tag to ENCODE ChIP-Seq in Alzheimer's Disease Samples
- Chromatin Profiling: From ChIP to CUT&RUN, CUT&Tag and CUTAC
- Development of Site-Specific ChIP Technologies
- Multiple Challenges in ChIP
Protocols
- TechNote: Sonication Recommendations for ChIP
- ChIP-IT® Express: Supplemental Protocol for Suspension Cells
Publications
Search our database of customer publications for ChIP applications.
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