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Tools to analyze nuclear function,
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Active Motif

c-Myc Toolbox

The c-Myc oncogene encodes a transcription factor whose broad effects trigger selective gene expression amplification to promote cell growth and proliferation. Myc is one of the top targets for the development of cancer therapeutic options.

Active Motif can support early stage c-Myc research, screening and compound mechanism-of-action studies with our range of c-Myc products and services.


c-Myc Binding Assay
c-Myc Trans AM

Product:  c-Myc TransAM®

Function: Measures Global c-Myc binding
                activity.

Starting Material: Nuclear Extract

Throughput: Mid

Notes:  Immobilized c-Myc E-box binding site
            used to bind and capture active c-Myc
            on a 96-stripwell plate. Nuclear extracts
            are prepared using Active Motif's
            Nuclear Extract Kit.



Cell-based c-Myc Assays
C-Myc Luciferase Assay System

Product:    LightSwitch™ Promoter Reporter
                 Collection


Function:  Screen cells for c-Myc activity

Starting Material: Cells

Throughput: High

Notes: Both Synthetic c-Myc luciferase reporter
           vectors
and pre-cloned reporter vectors
           with c-Myc responsive gene promoters
           (e.g. TP53 and TERT) are available.



c-Myc Antibodies & Recombinant Proteins
C-Myc Antibodies

Product:  c-Myc antibodies & Rec. Proteins

Function: Validated for WB, EMSA, & IP

Note: Validated to work in our TransAM and
          EMSA Kits.



Genome-wide c-Myc Profiles
C-Myc Services

Product:   End-to-end ChIP-Seq Services

Function: Identify c-Myc binding across all
                genomic locations

Starting Material: Cells

Notes: End to end service, performed by our
           ChIP-Seq experts using our validated
           protocols and antibodies. Simply send
           us your frozen cells and we will send
           back analyzed data.



miRNA Regulation of c-Myc
Mouse

Products:  LightSwitch 3´UTR & miRNA
                 Reporter Collections


Function: Measure miRNA regulation of c-Myc.

Starting Material: Cells

Throughput: High

Notes: 3´UTR reporter constructs are available
           for c-Myc, E2F, and other c-Myc pathway
           related genes. A large collection of
           miRNA mimics are also available
           including those known to be regulated
           by c-Myc or to interact with
           c-Myc transcripts (mir34a, mir451).