Active Motif’s FactorPath™ ChIP-Seq Service can be used to map the binding of transcription factors on a genome-wide scale. Researchers use our FactorPath ChIP-Seq Service for many applications, including identifying the consensus binding motifs of poorly characterized transcription factors and mapping changes in the binding patterns of transcription factors in response to drug treatments.
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ChIP-Seq was performed using chromatin from a human melanoma cell line (2.5 million cells) and a MITF (Microphthalmia-associated Transcription Factor) monoclonal antibody (Catalog No. 39789). ChIP DNA was sequenced on the Illumina GA II and 19 million sequence tags were mapped to identify MITF binding sites across the genome. The image shows hundreds of MITF binding sites across a 60 million bp region on chromosome 9.