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Karmella Haynes headshot

Synthetic Chromatin Epigenetics (Karmella Haynes)

Episode 52

July 8, 2021

In this episode of the Epigenetics Podcast, we caught up with Dr. Karmella Haynes from Emory University to talk about her work on synthetic chromatin epigenetics, specifically on the design of synthetic chromatin sensor proteins. The first one of its kind, the Polycomb Transcription Factor (PcTF), senses H3K27me3 and recruits effector proteins to the sites of this modification. This sensor can be brought into cancer cells to activate hundreds of silenced genes. The lab hopes to characterize these effects genome wide and seeks to find a way to deliver those sensor into cancer cells, without affecting healthy cells.

In this Episode we discuss how Karmella Haynes got into the field of Epigenetics and the way she came to learn how important the right control experiments are. In the end we also discuss her activities to promote diversity and inclusion in science.