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Active Motif has a collection of small-molecule epigenetic modulators (activators and inhibitors) that target changes to DNA methylation and chromatin remodeling proteins, such as histones. These include targets to DNA Methyltransferases (DNMTs), Histone Acetyltransferases (HATs), Histone Deacetylases (HDACs), Histone Methyltransferases (HMTs), Histone Demethylases (HDMs) and a distinct set of chromatin readers, bromodomains. As epigenetic dysregulation is implicated in many diseases, these modulators represent important tools for researchers in their assay development and drug discovery initiatives.
A list of the available activators and inhibitors for epigenetic research is shown below. Please click on the small molecule name to view complete product information.
| Name | Appl. | Format | Cat No. | Price | |
|---|---|---|---|---|---|
| 2'-Deoxy-5-fluorocytidine | DNMT Inhibitor | 250 mg | 14108 | $420 | Add to Cart |
| 50 mg | 14109 | $105 | Add to Cart | ||
| 5-Aza-2'-deoxycytidine (Decitabine) | DNMT Inhibitor | 50 mg | 14100 | $425 | Add to Cart |
| 10 mg | 14101 | $120 | Add to Cart | ||
| 5-Azacytidine | DNMT Inhibitor | 250 mg | 14102 | $95 | Add to Cart |
| 50 mg | 14103 | $45 | Add to Cart | ||
| 6-Thioguanine | DNMT Inhibitor | 1 g | 14126 | $135 | Add to Cart |
| 100 mg | 14127 | $45 | Add to Cart | ||
| AK-7 | SIRT2 Inhibitor | 25 mg | 14054 | $275 | Add to Cart |
| 5 mg | 14055 | $75 | Add to Cart | ||
| Apicidin | HDAC Inhibitor | 5 mg | 14040 | $295 | Add to Cart |
| 1 mg | 14041 | $85 | Add to Cart | ||
| Arecoline hydrobromide | ACAT1 Inhibitor | 1 g | 14132 | $95 | Add to Cart |
| 250 mg | 14133 | $45 | Add to Cart | ||
| AS-8351 | KDM5B Inhibitor | 25 mg | 14112 | $215 | Add to Cart |
| 5 mg | 14113 | $65 | Add to Cart | ||
| Biotin-14-dATP | N/A | 1 mg | 14138 | $1,320 | Add to Cart |
| 200 µg | 14139 | $325 | Add to Cart | ||
| BIX-01294 | G9a/GLP Inhibitor | 25 mg | 14072 | $500 | Add to Cart |
| 5 mg | 14073 | $120 | Add to Cart |
