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Active Motif has a collection of small-molecule epigenetic modulators (activators and inhibitors) that target changes to DNA methylation and chromatin remodeling proteins, such as histones. These include targets to DNA Methyltransferases (DNMTs), Histone Acetyltransferases (HATs), Histone Deacetylases (HDACs), Histone Methyltransferases (HMTs), Histone Demethylases (HDMs) and a distinct set of chromatin readers, bromodomains. As epigenetic dysregulation is implicated in many diseases, these modulators represent important tools for researchers in their assay development and drug discovery initiatives.
A list of the available activators and inhibitors for epigenetic research is shown below. Please click on the small molecule name to view complete product information.
| Name | Appl. | Format | Cat No. | Price | |
|---|---|---|---|---|---|
| 2'-Deoxy-5-fluorocytidine | DNMT Inhibitor | 250 mg | 14108 | $400 | Buy |
| 50 mg | 14109 | $100 | Buy | ||
| 5-Aza-2'-deoxycytidine (Decitabine) | DNMT Inhibitor | 50 mg | 14100 | $405 | Buy |
| 10 mg | 14101 | $115 | Buy | ||
| 5-Azacytidine | DNMT Inhibitor | 250 mg | 14102 | $90 | Buy |
| 50 mg | 14103 | $40 | Buy | ||
| 6-Thioguanine | DNMT Inhibitor | 1 g | 14126 | $130 | Buy |
| 100 mg | 14127 | $40 | Buy | ||
| AK-7 | SIRT2 Inhibitor | 25 mg | 14054 | $260 | Buy |
| 5 mg | 14055 | $70 | Buy | ||
| Apicidin | HDAC Inhibitor | 5 mg | 14040 | $280 | Buy |
| 1 mg | 14041 | $80 | Buy | ||
| Arecoline hydrobromide | ACAT1 Inhibitor | 1 g | 14132 | $90 | Buy |
| 250 mg | 14133 | $40 | Buy | ||
| AS-8351 | KDM5B Inhibitor | 25 mg | 14112 | $205 | Buy |
| 5 mg | 14113 | $60 | Buy | ||
| Biotin-14-dATP | N/A | 1 mg | 14138 | $1,260 | Buy |
| 200 µg | 14139 | $310 | Buy | ||
| BIX-01294 | G9a/GLP Inhibitor | 25 mg | 14072 | $475 | Buy |
| 5 mg | 14073 | $115 | Buy |
