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Histone methyltransferases (HMT) are histone-modifying enzymes that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues on histone proteins. Methylation of arginine residues is catalyzed by protein arginine methyltransferases (PRMTs) while histone methyltransferases (HMTs) are responsible for lysine methylation. The removal of these histone marks from arginine and lysine residues is catalyzed by protein arginine demethylase (PRDM) and lysine demethylase (KDM) enzymes, respectively.
The methylation of histones is an important post-translational modification that is involved in regulating genome compaction and gene expression. Depending on the amino acid target, methylation can lead to either transcriptional repression or activation.
Active Motif offers a large number of active, recombinant HMT and HDM proteins available in small scale and bulk quantities.
