Histone Methyltransferases (HMTs) and Histone Demethylases (HDMs)

active, recombinant HMT and HDM proteins

Histone methyltransferases (HMT) are histone-modifying enzymes that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues on histone proteins. Methylation of arginine residues is catalyzed by protein arginine methyltransferases (PRMTs) while histone methyltransferases (HMTs) are responsible for lysine methylation. The removal of these histone marks from arginine and lysine residues is catalyzed by protein arginine demethylase (PRDM) and lysine demethylase (KDM) enzymes, respectively.

The methylation of histones is an important post-translational modification that is involved in regulating genome compaction and gene expression. Depending on the amino acid target, methylation can lead to either transcriptional repression or activation.

Active Motif offers a large number of active, recombinant HMT and HDM proteins available in small scale and bulk quantities.

 
Name Expressed In Format Cat No. Price  
Recombinant DOT1L (1-416) protein E. coli 50 µg 31474 $410 Buy
1 mg 31874 $2,900 Buy
Recombinant EHMT1 (894-1298) protein E. coli 50 µg 31520 $410 Buy
1 mg 31920 $2,900 Buy
Recombinant EHMT2 (G9a) protein Baculovirus 20 µg 31410 $405 Buy
1 mg 31810 $3,500 Buy
Recombinant EHMT2 (G9A)-SET (913-1193) protein E. coli 50 µg 31425 $410 Buy
1 mg 31825 $2,900 Buy
Recombinant EZH1 complex Baculovirus 20 µg 31500 $435 Buy
1 mg 31904 $3,800 Buy
Recombinant EZH2 protein complex Baculovirus 25 µg 31337 $405 Buy
Recombinant FBXL10 / KDM2B protein Baculovirus 20 µg 31455 $410 Buy
Recombinant JARID1A / KDM5A protein Baculovirus 20 µg 31431 $410 Buy
1 mg 31831 $3,800 Buy
Recombinant JARID1B / KDM5B protein Sf9 cells 20 µg 31432 $410 Buy
1 mg 31832 $3,800 Buy
Recombinant JARID1B / KDM5B (2-751) protein Baculovirus 20 µg 31518 $410 Buy