Bromodomains

recombinant bromodomain-containing proteins

Bromodomain proteins play an integral role in the regulation of transcription and chromatin remodeling by acting as 'readers' of acetylated histone lysine residues. The bromodomain (BRD) primarily functions to anchor associated protein complexes to acetylated chromatin, thus regulating its structure and transcriptional potential. Additionally, the BRD is the only protein domain known to specifically recognize and bind acetylated lysine residues on histone tails, although it is also known to bind to non-histone acetylated lysine targets.

The diverse set of bromodomain proteins includes histone acetyltransferases (GCN5, PCAF), methyltransferases (MLL, ASH1L), helicases (SMARCA), transcriptional coactivators (TRIM, TAFs), nuclear scaffolding proteins (PBRM1), ATP-dependent chromatin-remodeling complex proteins and bromodomain extra-terminal (BET) family proteins.

Active Motif offers a large number of high quality, recombinant bromodomain-containing proteins. Note that all are available in small scale and bulk quantities. Click on the protein name to see complete information.

 
Name Expressed In Format Cat No. Price  
Recombinant ASH1L (2407-2579) protein E. coli 100 µg 31445 $410 Buy
1 mg 31845 $2,700 Buy
Recombinant BPTF / FALZ (2791-2911) protein E. coli 100 µg 31447 $410 Buy
1 mg 31847 $2,700 Buy
Recombinant BRD1 (556-688) protein E. coli 100 µg 31438 $410 Buy
1 mg 31838 $2,300 Buy
Recombinant BRD2 (BD1+BD2) protein E. coli 50 µg 81435 $410 Buy
1 mg 81535 $2,700 Buy
Recombinant BRD2 (71-194) protein E. coli 100 µg 31442 $360 Buy
1 mg 31842 $2,700 Buy
Recombinant BRD2 (71-194) protein, GST-Tag E. coli 100 µg 81149 $410 Buy
1 mg 81849 $2,300 Buy
Recombinant BRD2 (344-455) protein E. coli 100 µg 31378 $360 Buy
1 mg 31778 $2,300 Buy
Recombinant BRD2 (344-455) protein, GST-Tag E. coli 100 µg 81150 $410 Buy
1 mg 81850 $2,300 Buy
Recombinant BRD3 (BD1+BD2) protein E. coli 50 µg 81436 $410 Buy
1 mg 81536 $2,700 Buy
Recombinant BRD3 (24-144) protein E. coli 100 µg 31379 $360 Buy
1 mg 31779 $2,300 Buy