HPA (Hexyl-4-pentynoic acid)
|Aliases: 2-(2-propynyl)octanoic acid (racemic)|
|Catalog No: 14034||Format: 50 mg||$110||Buy|
|Catalog No: 14035||Format: 10 mg||$45||Buy|
|Application: Histone Acetylation (HAT & HDAC)|
MW = 182.3
>97% (TLC); NMR (Conforms)
Valproic acid analog. Histone deacetylase (HDAC) inhibitor (IC50 = 13 M)(ref 1). More potent and robust than valproic acid at inducing histone hyperacetylation (600% at 50 M), HSP70 induction and protection against glutamate excitotoxicity in cultured neurons (ref 2). Cell permeable.
Colorless oil. May be dissolved in DMSO (25 mg/ml); Ethanol (25 mg/ml).
Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.
1. D Eikel et al. Chem. Res. Toxicol. 2006, 19:272
2. Y Leng et al. Neurosci. Lett. 2010, 476:127