HPA (Hexyl-4-pentynoic acid)

Aliases: 2-(2-propynyl)octanoic acid (racemic)
Catalog No: 14034 Format: 50 mg $110 Buy
Catalog No: 14035 Format: 10 mg $45 Buy

Application: Histone Acetylation (HAT & HDAC)

Chemical Properties

MW = 182.3
CAS 96017-59-3
>97% (TLC); NMR (Conforms)


Valproic acid analog. Histone deacetylase (HDAC) inhibitor (IC50 = 13 M)(ref 1). More potent and robust than valproic acid at inducing histone hyperacetylation (600% at 50 M), HSP70 induction and protection against glutamate excitotoxicity in cultured neurons (ref 2). Cell permeable.


Colorless oil. May be dissolved in DMSO (25 mg/ml); Ethanol (25 mg/ml).

Storage Conditions

Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.


1. D Eikel et al. Chem. Res. Toxicol. 2006, 19:272
2. Y Leng et al. Neurosci. Lett. 2010, 476:127


Chemical structure of HPA.