Tranylcypromine hemisulfate

Aliases: 2-PCPA, trans-2-phenylcyclopropanamine
Catalog No: 14046 Format: 250 mg $150 Buy
Catalog No: 14047 Format: 50 mg $45 Buy
Application: Histone Methylation (HMT & HDM)

Chemical Properties

MW = 182.2
C9H11N • 1/2 H2SO4
CAS 13492-01-8
>98% (TLC); NMR (Conforms)

Description

Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) (IC50 less than 2 µM) (ref 1,2). Tranylcypromine treatment of P19 embryonal carcinoma cells resulted in global increase of H3K4 methylation along with transcriptional derepression of two BHC110 target genes, Egr1 and Oct4. When combined with CHIR99021, induces the generation of human-induced pluripotent stem cells in the absence of Sox2 (ref 3). Reduces proliferation, cell cycle progression and invasiveness of endometriotic stromal cells (ref 4). Upregulates CD86 expression in THP1 cells (ref 5). Cell permeable and active in vivo.

Contents

White solid. May be dissolved in water (25 mg/ml).

Storage Conditions

Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 1 month.

References

1. NG Lee et al. Bhem. Biol. 2006, 13:563
2. DM Schmidt and DG McCafferty Biochemistry 2007, 46:4408
3. W Li et al. Stem Cells 2009, 27:2992
4. D Ding et al. Fertil. Steril. 2014, 101:740
5. JT Lynch et al. Anal. Biochem. 2013, 442:104

 
Chemical structure of Tranylcypromine hemisulfate.

Chemical structure of Tranylcypromine hemisulfate.