Aliases: IOX-1, 8-Hydroxy-5-quinolinecarboxylic acid; 5-Carboxy-8HQ
Catalog No: 14056 Format: 25 mg $290 Buy
Catalog No: 14057 Format: 5 mg $75 Buy
Application: Histone Methylation (HMT & HDM)

Chemical Properties

MW = 189.2
CAS 5852-78-8
>98% (HPLC); NMR (Conforms)


Inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6 and 1 M for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively (ref 1). A broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling (ref 1). Cell permeable.


Yellow powder. May be dissolved in DMSO (20 mg/ml).

Storage Conditions

Store desiccated as supplied at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.


1. ON King et al. PLoS One 2010, 5:e15535

Chemical structure of IOX1.

Chemical structure of IOX1.