GSK-J4 (cell permeable)

Aliases: N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Catalog No: 14070 Format: 25 mg $320 Buy
Catalog No: 14071 Format: 5 mg $80 Buy
Application: Histone Methylation (HMT & HDM)

Chemical Properties

MW = 417.5
CAS 1373423-53-0
>99% (TLC); NMR (Conforms)


Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 µM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J1 (Catalog No. 14068)(ref 1). Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies (ref 2).


Yellow wax. May be dissolved in DMSO (40 mg/ml); Ethanol (40 mg/ml).

Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.


1. L Kruidenier et al. Nature 2012, 488:404
2. SI Inoue et al. Hum. Mol. Genet. 2014 July 17, Epub.

Chemical structure of GSK-J4.

Chemical structure of GSK-J4.