Splitomicin
Aliases: Splitomycin, 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one |
Catalog No: 14086 | Format: 25 mg | $250 | Add to Cart |
Catalog No: 14087 | Format: 5 mg | $65 | Add to Cart |
Application: Sirtuins |
Chemical Properties
MW = 198.2
C13H10O2
CAS 5690-03-9
>98% (TLC); NMR (Conforms)
Description
Initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae (ref 1). Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA (ref 1). Inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome (ref 2). Reverses ischemic preconditioning-induced cardioprotection in a mouse model (ref 3).
Contents
White powder. May be dissolved in DMSO (>25 mg/ml); Ethanol (>25 mg/ml).
Storage Conditions
Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 1 month.
References
1. A Bedalov et al. Proc. Natl. Acad. Sci. USA 2001, 98:15113
2. R Biacsi et al. PLoS Genet. 2008, 4(3):e1000017
3. SM Nadtochiy et al. Cardiovasc. Res. 2011, 89:643