TM-2-51

Aliases: 1-Benzoyl-3-phenyl-2-thiourea
Catalog No: 14096 Format: 50 mg $205 Buy
Catalog No: 14097 Format: 10 mg $60 Buy
Application: Histone Acetylation (HAT & HDAC)

Chemical Properties

MW = 256.3
C14H12N2OS
CAS 4921-82-8
>98% (TLC); NMR (Conforms)

Description

Highly potent and isozyme selective activator of recombinant HDAC8. Increases the activity of HDAC8 by a factor of 12 at 10 µM (ref1). No activation of other HDACs is observed. Rescues the activity of catalytically compromised HDAC8 mutants in vitro (ref2).

Contents

Beige powder. May be dissolved in DMSO (50 mg/ml); Ethanol (8 mg/ml).

Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.

References

1. RK Singh et al. Bioorg. Med. Chem. Lett. 2011, 21:5920
2. C Decroos et al. ACS Chem. Biol. 2014, 9:2157

 
Chemical structure of TM-2-51.

Chemical structure of TM-2-51.