TC-E-5003

Aliases: N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)
Catalog No: 14099 Format: 50 mg $70 Buy
Application: Histone Methylation (HMT & HDM)

Chemical Properties

MW = 401.3
C16H14Cl2N2O4S
CAS 17328-16-4
>98% (TLC); NMR (Conforms)

Description

Selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 µM) . Displays no activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF-7 breast cancer cells and LNCaP prostate cancer cells. Blocks androgen-induced gene expression in LNCaP cells (ref1).

Contents

White powder. May be dissolved in DMSO (50 mg/ml); DMF (50 mg/ml); Ethanol (nil).

Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.

References

1. EM Bissinger et al. Bioorg. Med. Chem. Lett. 2011, 19:3717

 
Chemical structure of TC-E-5003.

Chemical structure of TC-E-5003.