|Aliases: Decitabine, 5-Aza-2'-deoxycytidine; NSC-127716|
|Catalog No: 14100||Format: 50 mg||$405||Buy|
|Catalog No: 14101||Format: 10 mg||$115||Buy|
|Application: DNA Methylation|
MW = 228.2
MP = 193-196°C
>98% (TLC); NMR (Conforms)
Inhibits DNA methyltransferases (DNMT). Induces demethylation and reactivation of silenced genes suppressing the growth of human tumor cell lines (ref 1). Increases stem cell reprogramming efficiency. Stimulates osteogenic differentiation of human bone marrow stromal cells (ref 2). Induces differentiation and growth inhibition in IDH1 mutant glioma cells and decreases tumor growth in vivo (ref 3). Cell permeable.
White powder. May be dissolved in DMSO (25 mg/ml); Water (11 mg/ml); Ethanol (nil).
Store desiccated as supplied at 4°C for up to 2 years. Store solutions at -20°C for up to 3 months.
1. CM Bender et al. Cancer Res. 1998, 58:95
2. AT El-Serafi et al. Differentiation 2011, 81:35
3. S Turcan et al. Oncotarget 2013, 4:1729