5-Aza-2’-deoxycytidine (Decitabine)

Aliases: Decitabine, 5-Aza-2’-deoxycytidine; NSC-127716
Catalog No: 14100 Format: 50 mg $385 Buy
Catalog No: 14101 Format: 10 mg $105 Buy
Application: DNA Methylation

Chemical Properties

MW = 228.2
C8H12N4O4
CAS 2353-33-5
MP = 193-196°C
>98% (TLC); NMR (Conforms)

Description

Inhibits DNA methyltransferases (DNMT). Induces demethylation and reactivation of silenced genes suppressing the growth of human tumor cell lines (ref 1). Increases stem cell reprogramming efficiency. Stimulates osteogenic differentiation of human bone marrow stromal cells (ref 2). Induces differentiation and growth inhibition in IDH1 mutant glioma cells and decreases tumor growth in vivo (ref 3). Cell permeable.

Contents

White powder. May be dissolved in DMSO (25 mg/ml); Water (11 mg/ml); Ethanol (nil).

Storage Conditions

Store desiccated as supplied at 4°C for up to 2 years. Store solutions at -20°C for up to 3 months.

References

1. CM Bender et al. Cancer Res. 1998, 58:95
2. AT El-Serafi et al. Differentiation 2011, 81:35
3. S Turcan et al. Oncotarget 2013, 4:1729

 
Chemical structure of 5-Aza-2’-deoxycytidine (Decitabine).

Chemical structure of 5-Aza-2’-deoxycytidine (Decitabine).