SGC707

Aliases: 1-Isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-yl-ethyl)-urea, SGC707
Catalog No: 14130 Format: 25 mg $305 Buy
Catalog No: 14131 Format: 5 mg $80 Buy
Application: Histone Methylation (HMT & HDM)

Chemical Properties

MW = 298.3
C16H18N4O2
CAS 1687736-54-4
MP = 233-235°C
>98% (TLC); NMR (Conforms)

Description

Pharmacology: Potent and selective allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3)(ref 1). IC50 = 31 nM and selective against 31 other methyltransferases. An extremely useful probe for investigating the role of PRMT3 in normal and pathophysiology. Cell permeable and active in vivo.

Contents

Beige crystalline powder. May be dissolved in DMSO (35 mg/ml).

Storage Conditions

Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.

References

1. HU Kaniskan et al. Angew.Chem. Int. Ed. Engl. 2015, 54:5166<

 
Chemical structure of SGC707.

Chemical structure of SGC707.