MW = 428.0
>98% (TLC); NMR (Conforms)
Nicotinamide phosphoribosyltransferase (Nampt) inhibitor (Ki = 0.4 nM). FK-866 is a highly specific non-competitive inhibitor of Nampt causing gradual NAD+ depletion (ref 1). Induces tumor cell apoptosis (ref 1) and causes premature senescence in normal human smooth muscle cells which may be linked to decreased activity of the NAD+-dependent enzyme SIRT1 (ref 2). Extends lifespan of human cells. Cell permeable.
Off white powder (hygroscopic), MP = 92-96°C. May be dissolved in water (40 mg/ml).
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 2 months.
1. M Hasmann et al. Cancer Res. 2003, 63:7436
2. E van der Veer et al. J. Biol. Chem. 2007, 282:10841