FK-866 HCl

Catalog No: 14030 Format: 25 mg $300 Buy
Catalog No: 14031 Format: 5 mg $75 Buy
Application: Other

Chemical Properties

MW = 428.0
C24H29N3O2 HCl
CAS 658084-64-1
>98% (TLC); NMR (Conforms)

Description

Nicotinamide phosphoribosyltransferase (Nampt) inhibitor (Ki = 0.4 nM). FK-866 is a highly specific non-competitive inhibitor of Nampt causing gradual NAD+ depletion (ref 1). Induces tumor cell apoptosis (ref 1) and causes premature senescence in normal human smooth muscle cells which may be linked to decreased activity of the NAD+-dependent enzyme SIRT1 (ref 2). Extends lifespan of human cells. Cell permeable.

Contents

Off white powder (hygroscopic), MP = 92-96°C. May be dissolved in water (40 mg/ml).

Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 2 months.

References

1. M Hasmann et al. Cancer Res. 2003, 63:7436
2. E van der Veer et al. J. Biol. Chem. 2007, 282:10841

 
Chemical structure of FK-866.

Chemical structure of FK-866.