Apicidin

Aliases: Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl]
Catalog No: 14040 Format: 5 mg $265 Buy
Catalog No: 14041 Format: 1 mg $75 Buy
Application: Histone Acetylation (HAT & HDAC)

Chemical Properties

MW = 623.8
C34H49N5O6
CAS 183506-66-3
≥98% (HPLC); NMR (Conforms)

Description

Cyclopeptide inhibitor of histone deacetylases (HDACs) (ref 1). Inhibits HeLa cell proliferation (IC50 = 50-100 nM) and induces reversible transcriptional activation of p21 (WAF1) (ref 2). Decreases HIF1α protein levels and transcriptional activity in human and mouse tumor cell lines (ref 3). Cell permeable.

Contents

White solid. May be dissolved in DMSO (10 mg/ml).

Storage Conditions

Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.

References

1. SJ Darkin-Rattray et al. Proc. Natl. Acad. Sci. USA 1996, 93:13143
2. JW Han et al. Cancer Res. 2000, 60:6068
3. SH Kim et al. Oncol. Rep. 2007, 17:647

 
Chemical structure of Apicidin.

Chemical structure of Apicidin.