DMOG

Aliases: N-(2-Methyoxy-2-oxoacetyl)glycine methyl ester; Dimethyloxalylglycine
Catalog No: 14062 Format: 50 mg $215 Buy
Catalog No: 14063 Format: 10 mg $65 Buy
Application: Histone Methylation (HMT & HDM)

Chemical Properties

MW = 175.1
C6H9NO5
CAS 89464-63-1
MP = 46-48°C
>98% (TLC); NMR (Conforms)

Description

Inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1α (ref 1,2) and inhibiting JMJD2A (IC50 = 2.5 M) (ref 3). Displays neuroprotective effects. Inhibits neuronal cell death caused by neurotrophin deprivation (ref 4). Prevents activation of the ATR/CHK1/p53 pathway and suppresses apoptosis induced by DNA damage (ref 5).

Contents

White to off-white solid. May be dissolved in DMSO (30 mg/ml); Ethanol (25 mg/ml); Water (30 mg/ml).

Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.

References

1. TM Asikainen et al. Proc. Natl. Acad. Sci. USA 2005, 102:10212
2. P Jaakkola et al. Science 2001, 292:468
3. S Hamada et al. Bioorg. Med. Chem. Lett. 2009, 19:2852
4. DJ Lomb et al. Mol. Pharmacol. 2009, 75:1198
5. L Xie et al. Clin. Invest. 2012, 122:2827

 
Chemical structure of DMOG.

Chemical structure of DMOG.