Garcinol

Catalog No: 14076 Format: 50 mg $340 Buy
Catalog No: 14077 Format: 10 mg $80 Buy
Application: Histone Acetylation (HAT & HDAC)

Chemical Properties

MW = 602.8
C38H50O6
CAS 78824-30-3
>97% (TLC); NMR (Conforms)

Description

Potent inhibitor of histone acetyltransferases p300 (IC50 = 7 M) and pCAF (IC50 = 5 M)(ref 1). Induces apoptosis in various cell lines (ref 2). Promotes expansion of human hematopoietic stem cells (ref 3). Cell permeable.

Contents

Yellow solid. May be dissolved in DMSO (25 mg/ml); Ethanol (25 mg/ml).

Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 2 months.

References

1. K Balasubramanyam et al. J. Biol. Chem. 2004, 279:33716
2. MA Parasramka et al. Nutr. Cancer 2011, 63:456
3. T Nishino et al. PLoS One 2011, 6:e24298

 
Chemical structure of Garcinol.

Chemical structure of Garcinol.