SirtAct

Aliases: SirtAct, Sirt1 activator 3, CAY10591, 2-Amino-N-cyclopentyl-1-(3-methoxypropyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide
Catalog No: 14080 Format: 25 mg $380 Buy
Catalog No: 14081 Format: 5 mg $150 Buy
Application: Sirtuins

Chemical Properties

MW = 367.4
C20H25N5O2
CAS 839699-72-8
Physical Properties: Olive green powder
>98% (TLC); NMR (Conforms)

Description

Sirt1 activator. It suppressed TNFα release from THP-1 cells and stimulated adipogenesis in 3T3L1 cells (ref 1). SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice (ref 2). It inhibited NFκB activation and reduced inflammatory cytokine production in lamina propria mononuclear cells from IBD patients (ref 3). It prevented and cured experimental Colitis in a mouse model (ref 3).

Contents

Olive green powder. May be dissolved in DMSO (50 mg/ml); Ethanol (20 mg/ml, warm).

Storage Conditions

Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.

References

1. VM Nayagam et al. J. Biomol. Screen. 2006, 11:959
2. SS Barbieri et al. Circulation 2012, 126:1373
3. R Caruso et al. Mucosal Immunol. 2014, May 21 Epub

 
Chemical structure of SirtAct.

Chemical structure of Garcinol.